Flutamide. Mechanism of action of a new nonsteroidal antiandrogen

G. Sufrin, D. S. Coffey

Research output: Contribution to journalArticlepeer-review


Flutamide is a new nonsteroidal antiandrogen useful in the treatment of prostatic carcinoma. The mechanism of action of this compound was investigated using the sex accessory tissue of the male rat. Flutamide was found to block the action of both endogenous and exogenous testosterone and, in addition, to be a potent inhibitor of testosterone stimulated prostatic DNA synthesis. Moreover, it is capable of inhibiting prostatic nuclear uptake of androgen. Electron microscopic observations further confirm the antiandrogenic properties of flutamide.

Original languageEnglish (US)
Pages (from-to)429-434
Number of pages6
JournalInvestigative Urology
Issue number6
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Medicine(all)


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