"Flush before fill" in children receiving automated peritoneal dialysis

Bradley A. Warady, Eileen N. Ellis, Barbara A Fivush, Gary M. Lum, Steven R. Alexander, Eileen D. Brewer, Frank Ogrinc, Sandra L. Watkins

Research output: Contribution to journalArticle

Abstract

◆ Objective: To evaluate the impact of the "flush before fill" technique on the frequency of peritonitis in children receiving automated peritoneal dialysis (APD). ◆ Design: Randomized prospective multicenter study. ◆ Setting: Participating pediatric dialysis programs of the Pediatric Peritoneal Dialysis Study Consortium. ◆ Patients: 121 pediatric (<21 years of age) patients that had received peritoneal dialysis for ≥ 2 months and that were currently receiving APD were randomized to use (flush group) or non-use (no flush group) of the "flush before fill" option. 66 patients were followed for ≥ 12 months. ◆ Main Outcome Measure: Peritonitis rates. ◆ Results: Overall, patients enrolled in the flush group experienced a peritonitis rate of 1 infection every 16.8 patient months; patients in the no flush group experienced a rate of 1 infection every 12.6 patient months (p = 0.193). However, analysis by gender revealed the peritonitis rate of females in the flush group (1 infection every 44.7 patient months) to be significantly better than females in the no flush group (1 infection every 12.4 patient months) (p ≤ 0.01). There was no difference noted in the male patients. ◆ Conclusion: The use of the "flush before fill" option in pediatric patients receiving APD is associated with a marked improvement in the peritonitis rate of female but not male patients. Further study is indicated to explain the gender differences.

Original languageEnglish (US)
Pages (from-to)493-498
Number of pages6
JournalPeritoneal Dialysis International
Volume23
Issue number5
StatePublished - Sep 2003

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Peritoneal Dialysis
Peritonitis
Pediatrics
Infection
Multicenter Studies
Dialysis
Outcome Assessment (Health Care)
Prospective Studies

Keywords

  • Cycler
  • Flush before fill
  • Pediatric
  • Peritonitis

ASJC Scopus subject areas

  • Nephrology

Cite this

Warady, B. A., Ellis, E. N., Fivush, B. A., Lum, G. M., Alexander, S. R., Brewer, E. D., ... Watkins, S. L. (2003). "Flush before fill" in children receiving automated peritoneal dialysis. Peritoneal Dialysis International, 23(5), 493-498.

"Flush before fill" in children receiving automated peritoneal dialysis. / Warady, Bradley A.; Ellis, Eileen N.; Fivush, Barbara A; Lum, Gary M.; Alexander, Steven R.; Brewer, Eileen D.; Ogrinc, Frank; Watkins, Sandra L.

In: Peritoneal Dialysis International, Vol. 23, No. 5, 09.2003, p. 493-498.

Research output: Contribution to journalArticle

Warady, BA, Ellis, EN, Fivush, BA, Lum, GM, Alexander, SR, Brewer, ED, Ogrinc, F & Watkins, SL 2003, '"Flush before fill" in children receiving automated peritoneal dialysis', Peritoneal Dialysis International, vol. 23, no. 5, pp. 493-498.
Warady BA, Ellis EN, Fivush BA, Lum GM, Alexander SR, Brewer ED et al. "Flush before fill" in children receiving automated peritoneal dialysis. Peritoneal Dialysis International. 2003 Sep;23(5):493-498.
Warady, Bradley A. ; Ellis, Eileen N. ; Fivush, Barbara A ; Lum, Gary M. ; Alexander, Steven R. ; Brewer, Eileen D. ; Ogrinc, Frank ; Watkins, Sandra L. / "Flush before fill" in children receiving automated peritoneal dialysis. In: Peritoneal Dialysis International. 2003 ; Vol. 23, No. 5. pp. 493-498.
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