Fluoxetine gradually increases [125I]DOI-labelled 5-HT(2A/2C) receptors in the hypothalamus without changing the levels of G(q)- and G11- proteins

Q. Li, N. A. Muma, G. Battaglia, L. D. Van De Kar

Research output: Contribution to journalArticle

Abstract

The time course of fluoxetine-induced supersensitivity of hypothalamic 5-HT(2A/2C) receptors was examined. Daily injections of fluoxetine (7 or 14 days) significantly increased agonist ([125I]DOI)-labeled high-affinity- state 5-HT(2A/2C) receptors in the hypothalamus, but not frontal cortex. No change was observed in the density of [3H]ketanserin-labeled 5-HT(2A) receptors in either brain region. The levels of G(q)- and G11- proteins in the hypothalamus and cortex were not altered by fluoxetine. These results suggest that fluoxetine gradually increases the G-protein coupling of 5- HT(2A/2C) receptors without altering the levels of G(q)- or G11-proteins.

Original languageEnglish (US)
Pages (from-to)225-228
Number of pages4
JournalBrain research
Volume775
Issue number1-2
DOIs
StatePublished - Nov 14 1997
Externally publishedYes

Keywords

  • 5-HT
  • 5-HT receptor
  • Antidepressant
  • G-protein
  • Receptor coupling
  • SSRI
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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