Abstract
The time course of fluoxetine-induced supersensitivity of hypothalamic 5-HT(2A/2C) receptors was examined. Daily injections of fluoxetine (7 or 14 days) significantly increased agonist ([125I]DOI)-labeled high-affinity- state 5-HT(2A/2C) receptors in the hypothalamus, but not frontal cortex. No change was observed in the density of [3H]ketanserin-labeled 5-HT(2A) receptors in either brain region. The levels of G(q)- and G11- proteins in the hypothalamus and cortex were not altered by fluoxetine. These results suggest that fluoxetine gradually increases the G-protein coupling of 5- HT(2A/2C) receptors without altering the levels of G(q)- or G11-proteins.
Original language | English (US) |
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Pages (from-to) | 225-228 |
Number of pages | 4 |
Journal | Brain research |
Volume | 775 |
Issue number | 1-2 |
DOIs | |
State | Published - Nov 14 1997 |
Externally published | Yes |
Keywords
- 5-HT
- 5-HT receptor
- Antidepressant
- G-protein
- Receptor coupling
- SSRI
- Serotonin
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- Clinical Neurology
- Developmental Biology