Fluoxetine gradually increases [125I]DOI-labelled 5-HT(2A/2C) receptors in the hypothalamus without changing the levels of G(q)- and G11- proteins

Qian Li, N. A. Muma, G. Battaglia, L. D. Van De Kar

Research output: Contribution to journalArticle

Abstract

The time course of fluoxetine-induced supersensitivity of hypothalamic 5-HT(2A/2C) receptors was examined. Daily injections of fluoxetine (7 or 14 days) significantly increased agonist ([125I]DOI)-labeled high-affinity- state 5-HT(2A/2C) receptors in the hypothalamus, but not frontal cortex. No change was observed in the density of [3H]ketanserin-labeled 5-HT(2A) receptors in either brain region. The levels of G(q)- and G11- proteins in the hypothalamus and cortex were not altered by fluoxetine. These results suggest that fluoxetine gradually increases the G-protein coupling of 5- HT(2A/2C) receptors without altering the levels of G(q)- or G11-proteins.

Original languageEnglish (US)
Pages (from-to)225-228
Number of pages4
JournalBrain Research
Volume775
Issue number1-2
DOIs
StatePublished - Nov 14 1997
Externally publishedYes

Fingerprint

Gq-G11 GTP-Binding Protein alpha Subunits
Receptor, Serotonin, 5-HT2C
Receptor, Serotonin, 5-HT2A
Fluoxetine
Hypothalamus
Ketanserin
Frontal Lobe
GTP-Binding Proteins
Injections
Brain
Proteins

Keywords

  • 5-HT
  • 5-HT receptor
  • Antidepressant
  • G-protein
  • Receptor coupling
  • Serotonin
  • SSRI

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fluoxetine gradually increases [125I]DOI-labelled 5-HT(2A/2C) receptors in the hypothalamus without changing the levels of G(q)- and G11- proteins. / Li, Qian; Muma, N. A.; Battaglia, G.; Van De Kar, L. D.

In: Brain Research, Vol. 775, No. 1-2, 14.11.1997, p. 225-228.

Research output: Contribution to journalArticle

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