Fluoroquinolones in the treatment of bacterial keratitis

K. S. Bower; R. P. Kowalski; Y. J. Gordon

doi:10.1016/S0002-9394(14)70641-5

Fluoroquinolones in the treatment of bacterial keratitis

K. S. Bower, R. P. Kowalski, Y. J. Gordon

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

PURPOSE: We evaluated the potential role of three topical fluoroquinolones in the treatment of bacterial keratitis by means of a laboratory database. METHODS: Antibiotic susceptibilities were determined for 153 isolates from patients with bacterial keratitis. Results were analyzed for each fluoroquinolone individually and in combination with cefazolin. RESULTS: Predicted susceptibility to each cefazolin-fluoroquinolone combination (98.7%) was superior to that for single-agent therapy with ofloxacin (88.2%), ciprofloxacin (82.3%), or norfloxacin (80.4%) (P = .0002). A cefazolin- fluoroquinolone combination (98.7%) was comparable to a cefazolin-gentamicin combination (97.4%). CONCLUSIONS: Combination therapy with cefazolin and a fluoroquinolone offers a reasonable alternative for the treatment of bacterial keratitis. Single-agent therapy with fluoroquinolones for vision- threatening bacterial keratitis is not advised.

Original language	English (US)
Pages (from-to)	712-715
Number of pages	4
Journal	American journal of ophthalmology
Volume	121
Issue number	6
DOIs	https://doi.org/10.1016/S0002-9394(14)70641-5
State	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

Ophthalmology

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10.1016/S0002-9394(14)70641-5

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title = "Fluoroquinolones in the treatment of bacterial keratitis",

abstract = "PURPOSE: We evaluated the potential role of three topical fluoroquinolones in the treatment of bacterial keratitis by means of a laboratory database. METHODS: Antibiotic susceptibilities were determined for 153 isolates from patients with bacterial keratitis. Results were analyzed for each fluoroquinolone individually and in combination with cefazolin. RESULTS: Predicted susceptibility to each cefazolin-fluoroquinolone combination (98.7%) was superior to that for single-agent therapy with ofloxacin (88.2%), ciprofloxacin (82.3%), or norfloxacin (80.4%) (P = .0002). A cefazolin- fluoroquinolone combination (98.7%) was comparable to a cefazolin-gentamicin combination (97.4%). CONCLUSIONS: Combination therapy with cefazolin and a fluoroquinolone offers a reasonable alternative for the treatment of bacterial keratitis. Single-agent therapy with fluoroquinolones for vision- threatening bacterial keratitis is not advised.",

author = "Bower, {K. S.} and Kowalski, {R. P.} and Gordon, {Y. J.}",

note = "Funding Information: Accepted for publication Dec. 1, 1995. Department of Ophthalmology, University of Pittsburgh Medical Center. Supported by the Pennsylvania Lions Club, Pittsburgh, Pennsylvania, The Eye & Ear Institute, Pittsburgh, Pennsylvania, grant EY 08227 from the National Eye Institute, Bethesda, Maryland, and the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.",

year = "1996",

doi = "10.1016/S0002-9394(14)70641-5",

language = "English (US)",

volume = "121",

pages = "712--715",

journal = "American Journal of Ophthalmology",

issn = "0002-9394",

publisher = "Elsevier USA",

number = "6",

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T1 - Fluoroquinolones in the treatment of bacterial keratitis

AU - Bower, K. S.

AU - Kowalski, R. P.

AU - Gordon, Y. J.

N1 - Funding Information: Accepted for publication Dec. 1, 1995. Department of Ophthalmology, University of Pittsburgh Medical Center. Supported by the Pennsylvania Lions Club, Pittsburgh, Pennsylvania, The Eye & Ear Institute, Pittsburgh, Pennsylvania, grant EY 08227 from the National Eye Institute, Bethesda, Maryland, and the University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

PY - 1996

Y1 - 1996

N2 - PURPOSE: We evaluated the potential role of three topical fluoroquinolones in the treatment of bacterial keratitis by means of a laboratory database. METHODS: Antibiotic susceptibilities were determined for 153 isolates from patients with bacterial keratitis. Results were analyzed for each fluoroquinolone individually and in combination with cefazolin. RESULTS: Predicted susceptibility to each cefazolin-fluoroquinolone combination (98.7%) was superior to that for single-agent therapy with ofloxacin (88.2%), ciprofloxacin (82.3%), or norfloxacin (80.4%) (P = .0002). A cefazolin- fluoroquinolone combination (98.7%) was comparable to a cefazolin-gentamicin combination (97.4%). CONCLUSIONS: Combination therapy with cefazolin and a fluoroquinolone offers a reasonable alternative for the treatment of bacterial keratitis. Single-agent therapy with fluoroquinolones for vision- threatening bacterial keratitis is not advised.

AB - PURPOSE: We evaluated the potential role of three topical fluoroquinolones in the treatment of bacterial keratitis by means of a laboratory database. METHODS: Antibiotic susceptibilities were determined for 153 isolates from patients with bacterial keratitis. Results were analyzed for each fluoroquinolone individually and in combination with cefazolin. RESULTS: Predicted susceptibility to each cefazolin-fluoroquinolone combination (98.7%) was superior to that for single-agent therapy with ofloxacin (88.2%), ciprofloxacin (82.3%), or norfloxacin (80.4%) (P = .0002). A cefazolin- fluoroquinolone combination (98.7%) was comparable to a cefazolin-gentamicin combination (97.4%). CONCLUSIONS: Combination therapy with cefazolin and a fluoroquinolone offers a reasonable alternative for the treatment of bacterial keratitis. Single-agent therapy with fluoroquinolones for vision- threatening bacterial keratitis is not advised.

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JO - American Journal of Ophthalmology

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Fluoroquinolones in the treatment of bacterial keratitis

Abstract

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