Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1

Kaisar A. Talukder, Bijay K. Khajanchi, Mohammad A. Islam, Zhahirul Islam, Dilip K. Dutta, Mustafizur Rahman, Haruo Watanabe, Gopinath B. Nair, David A. Sack

Research output: Contribution to journalArticlepeer-review

Abstract

We examined the quinolone resistance-determining region (QRDR) of gyrA, gyrB, and parC of recently isolated fluoroquinolone-resistant S. dysenteriae type 1 strains from south Asia and compared data with fluoroquinolone- susceptible strains associated with previous epidemics of 1978, 1984, and 1994. In fluoroquinolone-resistant strains, double mutations (Ser83 → Leu, Asp87 → Asn or Gly) and a single mutation (Ser80 → Ile) were detected in the QRDRs of gyrA and parC, respectively.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalCurrent Microbiology
Volume52
Issue number2
DOIs
StatePublished - Feb 2006
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

Fingerprint Dive into the research topics of 'Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1'. Together they form a unique fingerprint.

Cite this