Fluoroquinolone resistance in the rectal carriage of men in an active surveillance cohort: Longitudinal analysis

Jason E. Cohen, Patricia Landis, Bruce Trock, Hiten D. Patel, Mark W. Ball, Paul G Auwaerter, Edward Schaeffer, H Ballentine Carter

Research output: Contribution to journalArticle

Abstract

Purpose Rectal swabs can identify men with fluoroquinolone resistant bacteria and decrease the infection rate after transrectal ultrasound guided prostate biopsy by targeted antimicrobial prophylaxis. We evaluated the rate of fluoroquinolone resistance in an active surveillance cohort with attention to factors associated with resistance and changes in resistance with time. Materials and Methods We evaluated 416 men with prostate cancer on active surveillance who underwent rectal swabs to assess the rate of fluoroquinolone resistance compared to that in men undergoing diagnostic transrectal ultrasound guided prostate biopsy. The chi-square test and Student t-test were used to compare categorical and continuous variables, respectively. Poisson regression analysis was used for multivariate analysis. Results On the initial swab fluoroquinolone resistance was found in 95 of 416 men (22.8%) on active surveillance compared to 54 of 221 (24.4%) in the diagnostic biopsy cohort (p = 0.675). Diabetes was found in 4.0% of the fluoroquinolone sensitive group vs 14.7% of the resistant group (p

Original languageEnglish (US)
Pages (from-to)552-556
Number of pages5
JournalJournal of Urology
Volume193
Issue number2
DOIs
StatePublished - Feb 1 2015

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Fluoroquinolones
Cohort Studies
Biopsy
Prostate
Chi-Square Distribution
Ultrasonography
Prostatic Neoplasms
Multivariate Analysis
Regression Analysis
Students
Bacteria
Infection

Keywords

  • biopsy
  • diabetes mellitus
  • drug resistance, bacterial
  • fluoroquinolones
  • prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Fluoroquinolone resistance in the rectal carriage of men in an active surveillance cohort : Longitudinal analysis. / Cohen, Jason E.; Landis, Patricia; Trock, Bruce; Patel, Hiten D.; Ball, Mark W.; Auwaerter, Paul G; Schaeffer, Edward; Carter, H Ballentine.

In: Journal of Urology, Vol. 193, No. 2, 01.02.2015, p. 552-556.

Research output: Contribution to journalArticle

Cohen, Jason E. ; Landis, Patricia ; Trock, Bruce ; Patel, Hiten D. ; Ball, Mark W. ; Auwaerter, Paul G ; Schaeffer, Edward ; Carter, H Ballentine. / Fluoroquinolone resistance in the rectal carriage of men in an active surveillance cohort : Longitudinal analysis. In: Journal of Urology. 2015 ; Vol. 193, No. 2. pp. 552-556.
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