Fluorine (19F) MRS and MRI in biomedicine

Jesús Ruiz-Cabello, Brad P. Barnett, Paul A Bottomley, Jeff W Bulte

Research output: Contribution to journalArticle

Abstract

Shortly after the introduction of 1H MRI, fluorinated molecules were tested as MR-detectable tracers or contrast agents. Many fluorinated compounds, which are nontoxic and chemically inert, are now being used in a broad range of biomedical applications, including anesthetics, chemotherapeutic agents, and molecules with high oxygen solubility for respiration and blood substitution. These compounds can be monitored by fluorine (19F) MRI and/or MRS, providing a noninvasive means to interrogate associated functions in biological systems. As a result of the lack of endogenous fluorine in living organisms, 19F MRI of 'hotspots' of targeted fluorinated contrast agents has recently opened up new research avenues in molecular and cellular imaging. This includes the specific targeting and imaging of cellular surface epitopes, as well as MRI cell tracking of endogenous macrophages, injected immune cells and stem cell transplants.

Original languageEnglish (US)
Pages (from-to)114-129
Number of pages16
JournalNMR in Biomedicine
Volume24
Issue number2
DOIs
StatePublished - Feb 2011

Fingerprint

Fluorine
Magnetic resonance imaging
Contrast Media
Cell Tracking
Molecular Imaging
Solubility
Anesthetics
Epitopes
Respiration
Stem Cells
Macrophages
Oxygen
Transplants
Imaging techniques
Molecules
Biological systems
Stem cells
Research
Blood
Substitution reactions

Keywords

  • Cellular imaging
  • Lung ventilation
  • Molecular imaging
  • MR contrast agent
  • Oxygen measurement
  • Perfluorocarbon

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Fluorine (19F) MRS and MRI in biomedicine. / Ruiz-Cabello, Jesús; Barnett, Brad P.; Bottomley, Paul A; Bulte, Jeff W.

In: NMR in Biomedicine, Vol. 24, No. 2, 02.2011, p. 114-129.

Research output: Contribution to journalArticle

Ruiz-Cabello, Jesús ; Barnett, Brad P. ; Bottomley, Paul A ; Bulte, Jeff W. / Fluorine (19F) MRS and MRI in biomedicine. In: NMR in Biomedicine. 2011 ; Vol. 24, No. 2. pp. 114-129.
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