Fluorine-18 fluorodeoxyglucose splenic uptake from extramedullary hematopoiesis after granulocyte colony-stimulating factor stimulation

Hussein M. Abdel-Dayem, Gerald Rosen, Hossam El-Zeftawy, Sleiman Naddaf, Mithilesh Kumar, Saadet Atay, Adrienne Cacavio

Research output: Contribution to journalArticlepeer-review

Abstract

Two patients with sarcoma, one with recurrent osteosarcoma of the spine and the other with metastatic synovial cell sarcoma, were treated with high- dose chemotherapy that produced severe leukopenia. The patients received granulocyte colony-stimulating factor (G-CSF) to stimulate the bone marrow (480 mg given subcutaneously twice daily for 5 to 7 days); their responses were seen as a marked increase in peripheral leukocyte count with no change in the erythrocyte or platelet counts. The patients had fluorine-18 fluorodeoxygluclose (F-18 FDG) imaging 24 hours after the end of G-CSF treatment. Diffusely increased uptake of F-18 FDG was seen in the bone marrow in both patients. In addition, markedly increased uptake in the spleen was noted in both, indicating that the spleen was the site of extramedullary hematopoiesis. The patients had no evidence of splenic metastases. The first patient had a history of irradiation to the dorsal spine, which was less responsive to G-CSF administration than was the nonirradiated lumbar spine.

Original languageEnglish (US)
Pages (from-to)319-322
Number of pages4
JournalClinical nuclear medicine
Volume24
Issue number5
DOIs
StatePublished - May 1 1999

Keywords

  • Bone marrow hyperplasia
  • Extramedullary hematopoiesis
  • Fluorine-18 fluorodeoxygluclose
  • Granulocyte colony-stimulating Factor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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