Fluorinated lipid constructs permit facile passage of molecular cargo into living cells

Laila Dafik, Venkateshwarlu Kalsani, Anthony Kar Lun Leung, Krishna Kumar

Research output: Contribution to journalArticlepeer-review

Abstract

(Figure Presented) Fluorinated lipids get rapidly internalized into living cells and are also displayed on the cell surface. The uptake of lipids is energy dependent and is likely via the clathrin-mediated endocytic pathway. Fluorinated lipids are 3-5-fold more efficient in acting as molecular transporters of noncovalently bound proteins than their hydrocarbon counterparts. These materials could serve as efficient molecular transporters for molecules that function in the cytoplasm such as short interfering RNAs (siRNAs).

Original languageEnglish (US)
Pages (from-to)12091-12093
Number of pages3
JournalJournal of the American Chemical Society
Volume131
Issue number34
DOIs
StatePublished - Sep 2 2009
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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