Fluorescent heterogeneities in turbid media: Limits for detection with dual-interfering sources excitation

X. Intes, Yu Chen, Xingde Li, B. Chance

Research output: Contribution to journalConference article

Abstract

A quantitative comparison between the single source and the dual-interfering sources configurations for the detection of fluorescent heterogeneities embedded in a piecewise highly scattering homogeneous fluorescent background was carried out. The study is based upon simulations using analytical solutions of the frequency domain diffuse photon density waves and practical signal-to-noise ratio considerations. Results show that the dual-interfering sources outperformed single source techniques for the detection of heterogeneities in terms of fluorophore concentration and lifetime contrast. To detect the same inhomogeneity, less concentration and lifetime contrast are required with dual-interfering sources.

Original languageEnglish (US)
Pages (from-to)3139-3142
Number of pages4
JournalAnnual Reports of the Research Reactor Institute, Kyoto University
Volume3
StatePublished - Dec 1 2001
Externally publishedYes
Event23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Istanbul, Turkey
Duration: Oct 25 2001Oct 28 2001

Keywords

  • Fluorescence
  • Light propagation in tissues
  • Phased-array imaging systems
  • Photon density waves
  • Photon migration

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Mechanical Engineering

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