Thirty-eight patients with presumed ocular histoplasmosis were studied by fluorescein angiography in different stages of the disease. In the nonhemorrhagic lesions, the area of retinal edema was clearly demonstrated in the angiograms as an area of late diffuse fluorescence which disappeared when the lesion healed. The structure of small hemorrhagic lesions was similar to that of nonhemorrhagic lesions and definite vessel loops could be demonstrated in a few of them in the central whitish elevation. In large hemorrhagic lesions, a network of large capillaries was always demonstrated and the changes in the size and shape of the lesions corresponded to changes in the vessel net. Fluorescein angiography offers an objective way of documenting the changes in hemorrhagic central lesions during different trials of therapy.
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