Fluid resuscitation with lactated Ringer’s solution vs normal saline in acute pancreatitis: A triple-blind, randomized, controlled trial

Enrique de-Madaria, Iván Herrera-Marante, Verónica González-Camacho, Laia Bonjoch, Noé Quesada-Vázquez, Isabel Almenta-Saavedra, Cayetano Miralles-Maciá, Nelly G. Acevedo-Piedra, Manuela Roger-Ibáñez, Claudia Sánchez-Marin, Rosa Osuna-Ligero, Ángel Gracia, Pere Llorens, Pedro Zapater, Vikesh K. Singh, Rocío Moreu-Martín, Daniel Closa

Research output: Contribution to journalArticle

Abstract

Background: Little is known regarding the optimal type of fluid resuscitation in acute pancreatitis (AP). Objective: The objective of this article was to compare the effect of lactated Ringer’s solution (LR) vs normal saline (NS) in the inflammatory response in AP. Methods: We conducted a triple-blind, randomized, controlled trial. Patients ≥ 18 admitted with AP were eligible. Patients were randomized to receive LR or NS. Primary outcome variables were number of systemic inflammatory response syndrome (SIRS) criteria at 24 hours, 48 hours and 72 hours and blood C-reactive protein (CRP) levels at 48 hours and 72 hours. In vitro complementary experiments were performed to further explore the interaction between pH, lactate and inflammation. Results: Nineteen patients receiving LR and 21 receiving NS were analyzed. The median (p25–p75) number of SIRS criteria at 48 hours were 1 (1–2) for NS vs 1 (0–1) for LR, p = 0.060. CRP levels (mg/l) were as follows: at 48 hours NS 166 (78–281) vs LR 28 (3–124), p = 0.037; at 72 hours NS 217 (59–323) vs LR 25 (3–169), p = 0.043. In vitro, LR inhibited the induction of inflammatory phenotype of macrophages and NF-κB activation. This effect was not observed when using Ringer’s solution without lactate, suggesting a direct anti-inflammatory effect of lactate. Conclusions: Lactated Ringer’s is associated with an anti-inflammatory effect in patients with acute pancreatitis.

Original languageEnglish (US)
Pages (from-to)63-72
Number of pages10
JournalUnited European Gastroenterology Journal
Volume6
Issue number1
DOIs
StatePublished - Feb 1 2018

Keywords

  • Acute pancreatitis
  • fluid resuscitation
  • lactated Ringer’s solution
  • randomized controlled trial
  • systemic inflammatory response syndrome/prevention and control

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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    de-Madaria, E., Herrera-Marante, I., González-Camacho, V., Bonjoch, L., Quesada-Vázquez, N., Almenta-Saavedra, I., Miralles-Maciá, C., Acevedo-Piedra, N. G., Roger-Ibáñez, M., Sánchez-Marin, C., Osuna-Ligero, R., Gracia, Á., Llorens, P., Zapater, P., Singh, V. K., Moreu-Martín, R., & Closa, D. (2018). Fluid resuscitation with lactated Ringer’s solution vs normal saline in acute pancreatitis: A triple-blind, randomized, controlled trial. United European Gastroenterology Journal, 6(1), 63-72. https://doi.org/10.1177/2050640617707864