TY - JOUR
T1 - Flow physics of normal and abnormal bioprosthetic aortic valves
AU - Seo, Jung Hee
AU - Zhu, Chi
AU - Resar, Jon
AU - Mittal, Rajat
N1 - Funding Information:
This work is supported by NSF through grant CBET-1511200. This research was conducted using computational resources at the Maryland Advanced Research Computing Center (MARCC).
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/12
Y1 - 2020/12
N2 - Flow physics of transvalvular flows in the aorta with bioprosthetic valves are investigated using computational modelling. For the efficient simulations of flow-structure-interaction in transvalvular flows, a simplified, reduced degree of freedom valve model is employed with a sharp interface immersed boundary based incompressible flow solver. Simulations are performed for normal as well as abnormal valves with reduced leaflet motion that models the effect of early leaflet thrombosis. The structure of the aortic jet and the hemodynamic stresses on the aortic wall are analysed to understand the hemodynamic impacts and possible long-term clinical implications of sub-clinical, reduced leaflet motion. The simulation results have shown that the reduced leaflet motion tilts the direction of aortic jet and generates stronger flow separation and re-attachment on the aortic wall downstream from the reduced motion leaflets. The modified flow pattern increases the wall pressure fluctuation and average wall shear stress on the downstream aortic wall, and results in the asymmetric oscillatory shear index distributions, which may have long-term clinical implications such as aortic wall damage and remodelling.
AB - Flow physics of transvalvular flows in the aorta with bioprosthetic valves are investigated using computational modelling. For the efficient simulations of flow-structure-interaction in transvalvular flows, a simplified, reduced degree of freedom valve model is employed with a sharp interface immersed boundary based incompressible flow solver. Simulations are performed for normal as well as abnormal valves with reduced leaflet motion that models the effect of early leaflet thrombosis. The structure of the aortic jet and the hemodynamic stresses on the aortic wall are analysed to understand the hemodynamic impacts and possible long-term clinical implications of sub-clinical, reduced leaflet motion. The simulation results have shown that the reduced leaflet motion tilts the direction of aortic jet and generates stronger flow separation and re-attachment on the aortic wall downstream from the reduced motion leaflets. The modified flow pattern increases the wall pressure fluctuation and average wall shear stress on the downstream aortic wall, and results in the asymmetric oscillatory shear index distributions, which may have long-term clinical implications such as aortic wall damage and remodelling.
KW - Fluid structure interaction
KW - Immersed boundary method
KW - Leaflet thrombosis
KW - Transcather aortic valve replacement
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U2 - 10.1016/j.ijheatfluidflow.2020.108740
DO - 10.1016/j.ijheatfluidflow.2020.108740
M3 - Article
AN - SCOPUS:85093673817
SN - 0142-727X
VL - 86
JO - International Journal of Heat and Fluid Flow
JF - International Journal of Heat and Fluid Flow
M1 - 108740
ER -