Abstract
Borna disease virus (BDV) infects astrocytes in the Lewis rat brain. BDV-infected astrocytes have been shown to express MHC class II in vitro but not in vivo. Using a sensitive fluorescence-activated cytometric technique, we now report the detection of MHC class II on freshly harvested S100- positive cells from BDV-infected rat brain, without an intervening in vitro culture step. These data support the hypothesis that astrocytes from BDV- infected rats express MHC class II on their surface and, thus, are potential participants in the encephalitic response to BDV infection.
Original language | English (US) |
---|---|
Pages (from-to) | 286-290 |
Number of pages | 5 |
Journal | Experimental Neurology |
Volume | 146 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1997 |
ASJC Scopus subject areas
- Neurology
- Developmental Neuroscience