TY - JOUR
T1 - Flipping the paradigm on malaria transmission-blocking vaccines
AU - Dinglasan, Rhoel R.
AU - Jacobs-Lorena, Marcelo
N1 - Funding Information:
We thank Fidel Zavala for helpful comments and Anil Ghosh for assistance with the figure. R.R.D. is a Ruth L. Kirschstein National Research Service Award recipient. The work described was supported by grants from the National Institutes of Health.
PY - 2008/8
Y1 - 2008/8
N2 - The idea of malaria transmission-blocking vaccines (TBVs) surfaced more than two decades ago. Since then, the research paradigm focused on developing TBVs that target surface antigens of parasite sexual stages. Only recently has an effort emerged that flipped this paradigm, targeting antigens of the parasite's obligate invertebrate vector, the Anopheles mosquito. Here, we review the current state of knowledge of mosquito-based TBVs and discuss the utility of this approach for future vaccine development.
AB - The idea of malaria transmission-blocking vaccines (TBVs) surfaced more than two decades ago. Since then, the research paradigm focused on developing TBVs that target surface antigens of parasite sexual stages. Only recently has an effort emerged that flipped this paradigm, targeting antigens of the parasite's obligate invertebrate vector, the Anopheles mosquito. Here, we review the current state of knowledge of mosquito-based TBVs and discuss the utility of this approach for future vaccine development.
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U2 - 10.1016/j.pt.2008.05.002
DO - 10.1016/j.pt.2008.05.002
M3 - Review article
C2 - 18599352
AN - SCOPUS:47649101526
SN - 1471-4922
VL - 24
SP - 364
EP - 370
JO - Trends in parasitology
JF - Trends in parasitology
IS - 8
ER -