Flipping the paradigm on malaria transmission-blocking vaccines

Rhoel R. Dinglasan, Marcelo Jacobs-Lorena

Research output: Contribution to journalReview article

Abstract

The idea of malaria transmission-blocking vaccines (TBVs) surfaced more than two decades ago. Since then, the research paradigm focused on developing TBVs that target surface antigens of parasite sexual stages. Only recently has an effort emerged that flipped this paradigm, targeting antigens of the parasite's obligate invertebrate vector, the Anopheles mosquito. Here, we review the current state of knowledge of mosquito-based TBVs and discuss the utility of this approach for future vaccine development.

Original languageEnglish (US)
Pages (from-to)364-370
Number of pages7
JournalTrends in parasitology
Volume24
Issue number8
DOIs
StatePublished - Aug 1 2008

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ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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