Flat-panel cone-beam CT: A novel imaging technology for image-guided procedures

J. H. Siewerdsen, D. A. Jaffray, G. K. Edmundson, W. P. Sanders, J. Wong, A. A. Martinez

Research output: Contribution to journalConference articlepeer-review

40 Scopus citations


The use of flat-panel imagers for cone-beam CT signals the emergence of an attractive technology for volumetric imaging, Recent investigations demonstrate volume images with high spatial resolution and soft-tissue visibility and point to a number of logistical characteristics (e.g., open geometry, volume acquisition in a single rotation about the patient, and separation of the imaging and patient support structures) that are attractive to a broad spectrum of applications. Considering application to image-guided (IG) procedures - specifically IG therapies - this paper examines the performance of flat-panel cone-beam CT in relation to numerous constraints and requirements, including time (i.e., speed of image acquisition), dose, and field-of-view. The imaging and guidance performance of a prototype flat-panel cone-beam CT system is investigated through the construction of procedure-specific tasks that test the influence of image artifacts (e.g., x-ray scatter and beam-hardening) and volumetric imaging performance (e.g., 3-D spatial resolution, noise, and contrast) - taking two specific examples in IG brachytherapy and IG vertebroplasty. For IG brachytherapy, a procedure-specific task is constructed which tests the performance of flat-panel cone-beam CT in measuring the volumetric distribution of Pd-103 permanent implant seeds in relation to neighboring bone and soft-tissue structures in a pelvis phantom. For IG interventional procedures, a procedure-specific task is constructed in the context of vertebroplasty performed on a cadaverized ovine spine, demonstrating the volumetric image quality in pre-, intra-, and post-therapeutic images of the region of interest and testing the performance of the system in measuring the volumetric distribution of bone cement (PMMA) relative to surrounding spinal anatomy. Each of these tasks highlights numerous promising and challenging aspects of flat-panel cone-beam CT applied to IG procedures.

Original languageEnglish (US)
Pages (from-to)435-444
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2001
Externally publishedYes
EventMedical Imaging 2001: Visualization, Display, and Image-Guided Procedures - San Diego, CA, United States
Duration: Feb 18 2001Feb 20 2001

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


Dive into the research topics of 'Flat-panel cone-beam CT: A novel imaging technology for image-guided procedures'. Together they form a unique fingerprint.

Cite this