Fitting of dynamic recurrent neural network models to sensory stimulus-response data

R. Ozgur Doruk, Kechen Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

We present a theoretical study aiming at model fitting for sensory neurons. Conventional neural network training approaches are not applicable to this problem due to lack of continuous data. Although the stimulus can be considered as a smooth time-dependent variable, the associated response will be a set of neural spike timings (roughly the instants of successive action potential peaks) that have no amplitude information. A recurrent neural network model can be fitted to such a stimulus-response data pair by using the maximum likelihood estimation method where the likelihood function is derived from Poisson statistics of neural spiking. The universal approximation feature of the recurrent dynamical neuron network models allows us to describe excitatory-inhibitory characteristics of an actual sensory neural network with any desired number of neurons. The stimulus data are generated by a phased cosine Fourier series having a fixed amplitude and frequency but a randomly shot phase. Various values of amplitude, stimulus component size, and sample size are applied in order to examine the effect of the stimulus to the identification process. Results are presented in tabular and graphical forms at the end of this text. In addition, to demonstrate the success of this research, a study involving the same model, nominal parameters and stimulus structure, and another study that works on different models are compared to that of this research.

Original languageEnglish (US)
Pages (from-to)449-469
Number of pages21
JournalJournal of Biological Physics
Volume44
Issue number3
DOIs
StatePublished - Sep 1 2018

Keywords

  • Excitatory neuron
  • Inhibitory neuron
  • Maximum likelihood estimation
  • Neural spiking
  • Recurrent neural network
  • Sensory neurons

ASJC Scopus subject areas

  • Biophysics
  • Atomic and Molecular Physics, and Optics
  • Molecular Biology
  • Cell Biology

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