First-trimester prediction of small-for-gestational age neonates incorporating fetal Doppler parameters and maternal characteristics

Viola Seravalli, Dana M. Block-Abraham, Ozhan M. Turan, Lauren E. Doyle, Jerome N. Kopelman, Robert O. Atlas, Chuka B. Jenkins, Miriam G. Blitzer, Ahmet Baschat

Research output: Contribution to journalArticlepeer-review

Abstract

Objective First-trimester screening for subsequent delivery of a small-for-gestational-age (SGA) infant typically focuses on maternal risk factors and uterine artery (UtA) Doppler. Our aim is to test if incorporation of fetal umbilical artery (UA) and ductus venosus (DV) Doppler improves SGA prediction. Study Design Prospective screening study of singletons at 11-14 weeks. Maternal characteristics, serum concentrations of pregnancy-associated plasma protein-A (PAPP-A) and free β-human chorionic gonadotropin are ascertained and UtA Doppler, UA, and DV Doppler studies are performed. These parameters are tested for their ability to predict subsequent delivery of a SGA infant. Results Among 2267 enrolled women, 191 (8.4%) deliver an SGA infant. At univariate analysis women with SGA neonates are younger, more frequently African-American (AA), nulliparous, more likely to smoke, have lower PAPP-A and free β-human chorionic gonadotropin levels. They have a higher incidence of UtA Doppler bilateral notching, higher mean UtA Doppler-pulsatility index z-scores (P

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Volume211
Issue number3
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Fetal Doppler
  • first-trimester screening
  • small for gestational age
  • umbilical artery
  • uterine artery

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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