Finite element modeling of brain tumor mass-effect from 3D medical images

Ashraf Mohamed, Christos Davatzikos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Motivated by the need for methods to aid the deformable registration of brain tumor images, we present a three-dimensional (3D) mechanical model for simulating large non-linear deformations induced by tumors to the surrounding encephalic tissues. The model is initialized with 3D radiological images and is implemented using the finite element (FE) method. To simulate the widely varying behavior of brain tumors, the model is controlled by a number of parameters that are related to variables such as the bulk tumor location, size, mass-effect, and peri-tumor edema extent. Model predictions are compared to real brain tumor-induced deformations observed in serial-time MRI scans of a human subject and 3 canines with surgically transplanted gliomas. Results indicate that the model can reproduce the real deformations with an accuracy that is similar to that of manual placement of landmark points to which the model is compared.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - 8th International Conference, Proceedings
Pages400-408
Number of pages9
DOIs
StatePublished - 2005
Event8th International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - Palm Springs, CA, United States
Duration: Oct 26 2005Oct 29 2005

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume3749 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other8th International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005
CountryUnited States
CityPalm Springs, CA
Period10/26/0510/29/05

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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