Fine tuning the immune response through B7-H3 and B7-H4

Kyung H. Yi, Lieping Chen

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


B7-H3 and B7-H4 belong to a new class of immune regulatory molecules, which primarily execute their functions in peripheral tissues to fine tune immune responses in target organs. In normal circumstances, while the mRNA for both molecules is broadly distributed, tight control at the post-transcriptional level is imposed. Under a pathogenic environment, such as inflammation and cancer, the control is often aberrant. Upon engaging their receptors, these molecules regulate the immune response in positive or negative ways depending on the expression and type of cells bearing the receptors. Thus, manipulation of the expression of these molecules and/or their receptors may represent a realistic opportunity to fine tune immune responses and to design new immunotherapeutic approaches.

Original languageEnglish (US)
Pages (from-to)145-151
Number of pages7
JournalImmunological Reviews
Issue number1
StatePublished - May 2009


  • Cell activation
  • Costimulation
  • Immunotherapies
  • Transgenic/knockout mice
  • Tumor immunity

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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