Fine-Tuning ER-β Structure with PTMs

Gerald Warren Hart, Kaoru Sakabe

Research output: Contribution to journalArticle

Abstract

Estrogen receptor β is differentially regulated by alternative O-GlcNAcylation/O-phosphorylation at Ser16. NMR, CD, and molecular dynamics analyses of model peptides [1] show that these alternative modifications induce different peptide conformations, providing a molecular basis for their differential regulation of protein function.

Original languageEnglish (US)
Pages (from-to)923-924
Number of pages2
JournalChemistry and Biology
Volume13
Issue number9
DOIs
StatePublished - Sep 2006

ASJC Scopus subject areas

  • Organic Chemistry

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