Fine-mapping the putative chromosome 17q21-22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis

Ethan M. Lange, Christiane M. Robbins, Elizabeth M. Gillanders, Siqun Lilly Zheng, Jianfeng Xu, Yunfei Wang, Kirsten A. White, Bao Li Chang, Lindsey A. Ho, Jeffrey M. Trent, John D. Carpten, William B. Isaacs, Kathleen A. Cooney

Research output: Contribution to journalArticlepeer-review

Abstract

Prostate cancer linkage studies have suggested the existence of a prostate cancer susceptibility gene on chromosome 17q21-22. We now report the results of an extended linkage analysis including 95 new multiplex prostate cancer families and 9 additional microsatellite markers resulting in a maximum LOD score of 2.99 at approximately 81-82 cM for all 453 pedigrees. Results from these 95 new pedigrees provide additional support for a chromosome 17q21-22 prostate cancer susceptibility gene. Inclusion of the 9 additional markers significantly reduced the size of the candidate region, as defined using a 1-LOD support interval, especially when focusing analyses on subsets of pedigrees with four or more confirmed affecteds or average age of diagnosis less than or equal to 65 years. A novel subset analysis of only those families (n = 147) that had four or more prostate cancer cases and an average age of prostate cancer diagnosis ≤ 65 years results in a maximum LOD score of 5.49 at 78 cM with a 1-LOD support interval of 10 cM. This large set of pedigrees with four more prostate cancer cases characterized by early-onset disease will serve as a useful resource for identifying the putative 17q21-22 prostate cancer susceptibility gene.

Original languageEnglish (US)
Pages (from-to)49-55
Number of pages7
JournalHuman genetics
Volume121
Issue number1
DOIs
StatePublished - Mar 2007

Keywords

  • Early onset
  • Linkage analysis
  • Prostate cancer
  • Subset analyses

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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