@article{3af3f9a5f1e140d282823dab829906cf,
title = "Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection",
abstract = "Approximately three quarters of acute hepatitis C (HCV) infections evolve to a chronic state, while one quarter are spontaneously cleared. Genetic predispositions strongly contribute to the development of chronicity. We have conducted a genome-wide association study to identify genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ancestries. We confirmed two previously reported significant associations, in the IL28B/IFNL4 and the major histocompatibility complex (MHC) regions, with spontaneous clearance in the European population. We further fine-mapped the association in the MHC to a region of about 50 kilo base pairs, down from 1 mega base pairs in the previous study. Additional analyses suggested that the association in MHC is stronger in samples from North America than those from Europe.",
author = "Hailiang Huang and Priya Duggal and Thio, {Chloe L.} and Rachel Latanich and Goedert, {James J.} and Alessandra Mangia and Cox, {Andrea L.} and Kirk, {Gregory D.} and Shruti Mehta and Jasneet Aneja and Laurent Alric and Donfield, {Sharyne M.} and Cramp, {Matthew E.} and Khakoo, {Salim I.} and Tobler, {Leslie H.} and Michael Busch and Alexander, {Graeme J.} and Rosen, {Hugo R.} and Edlin, {Brian R.} and Segal, {Florencia P.} and Lauer, {Georg M.} and Thomas, {David L.} and Daly, {Mark J.} and Chung, {Raymond T.} and Kim, {Arthur Y.}",
note = "Funding Information: This project was funded in whole or in part by the National Institute of Allergy and Infectious Diseases (U19AI088791 and AI082630), the Office of AIDS Research through the Center for Inherited Diseases at Johns Hopkins University, the National Institute on Drug Abuse (R01DA033541, R01DA013324, R01DA12568, and R01DA04334). The MACS is funded by the National Institute of Allergy and Infectious Diseases, with additional supplemental funding from the National Cancer Institute (UO1-AI-35042, UL1-RR025005, UO1-AI-35043, UO1-AI-35039, UO1-AI-35040, and UO1-AI-35041). The REVELL cohort was funded by R01HL076902. Swan cohort was funded by R01-DA16159, R01-DA21550, and UL1-RR024996. The HGDS is funded by the National Institutes of Health, National Institute of Child Health and Human Development, R01-HD-41224. Publisher Copyright: {\textcopyright} 2017 The Author(s).",
year = "2017",
month = dec,
day = "1",
doi = "10.1038/s41598-017-16011-2",
language = "English (US)",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}