Fine mapping of an Alzheimer Disease-associated gene encoding beta-amyloid protein

Edmund C. Jenkins; Evelyn A. Devine-Gage; Nikolaos K. Robakis; Xiu Lan Yao; W. Ted Brown; George E. Houck; Gloria Wolfe; Narayanarao Ramakrishna; Wayne P. Silverman; Henryk M. Wisniewski

doi:10.1016/0006-291X(88)90551-7

Fine mapping of an Alzheimer Disease-associated gene encoding beta-amyloid protein

Edmund C. Jenkins, Evelyn A. Devine-Gage, Nikolaos K. Robakis, Xiu Lan Yao, W. Ted Brown, George E. Houck, Gloria Wolfe, Narayanarao Ramakrishna, Wayne P. Silverman, Henryk M. Wisniewski

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We have sublocalized an Alzheimer Disease-associated gene, which encodes for cerebrovascular beta-amyloid protein, to the region from the centromere through the proximal half of band 21q21 using both somatic cell and insitu mapping techniques. In addition we found repeatedly significant but weaker hybridization of the beta-amyloid protein probe to the short arm of chromosome 20. 794 cells were analyzed from whole blood, lymphoblastoid and skin cultures. The latter two types of cultures had parts of the 21st chromosome translocated to other chromosomes facilitating sublocalization.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	151
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(88)90551-7
State	Published - Feb 29 1988
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(88)90551-7

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title = "Fine mapping of an Alzheimer Disease-associated gene encoding beta-amyloid protein",

abstract = "We have sublocalized an Alzheimer Disease-associated gene, which encodes for cerebrovascular beta-amyloid protein, to the region from the centromere through the proximal half of band 21q21 using both somatic cell and insitu mapping techniques. In addition we found repeatedly significant but weaker hybridization of the beta-amyloid protein probe to the short arm of chromosome 20. 794 cells were analyzed from whole blood, lymphoblastoid and skin cultures. The latter two types of cultures had parts of the 21st chromosome translocated to other chromosomes facilitating sublocalization.",

author = "Jenkins, {Edmund C.} and Devine-Gage, {Evelyn A.} and Robakis, {Nikolaos K.} and Yao, {Xiu Lan} and Brown, {W. Ted} and Houck, {George E.} and Gloria Wolfe and Narayanarao Ramakrishna and Silverman, {Wayne P.} and Wisniewski, {Henryk M.}",

note = "Funding Information: ACKNOWLEDGEMENTS: We thank Mr. R. G. Weed and Ms. M. E. Nascimento for artistic assistance. This work was partially supported by NIH Grant and 1 PO1 HD22634. FAD-G was a fellow of the National Down Syndrome Society.",

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T1 - Fine mapping of an Alzheimer Disease-associated gene encoding beta-amyloid protein

AU - Jenkins, Edmund C.

AU - Devine-Gage, Evelyn A.

AU - Robakis, Nikolaos K.

AU - Yao, Xiu Lan

AU - Brown, W. Ted

AU - Houck, George E.

AU - Wolfe, Gloria

AU - Ramakrishna, Narayanarao

AU - Silverman, Wayne P.

AU - Wisniewski, Henryk M.

N1 - Funding Information: ACKNOWLEDGEMENTS: We thank Mr. R. G. Weed and Ms. M. E. Nascimento for artistic assistance. This work was partially supported by NIH Grant and 1 PO1 HD22634. FAD-G was a fellow of the National Down Syndrome Society.

PY - 1988/2/29

Y1 - 1988/2/29

N2 - We have sublocalized an Alzheimer Disease-associated gene, which encodes for cerebrovascular beta-amyloid protein, to the region from the centromere through the proximal half of band 21q21 using both somatic cell and insitu mapping techniques. In addition we found repeatedly significant but weaker hybridization of the beta-amyloid protein probe to the short arm of chromosome 20. 794 cells were analyzed from whole blood, lymphoblastoid and skin cultures. The latter two types of cultures had parts of the 21st chromosome translocated to other chromosomes facilitating sublocalization.

AB - We have sublocalized an Alzheimer Disease-associated gene, which encodes for cerebrovascular beta-amyloid protein, to the region from the centromere through the proximal half of band 21q21 using both somatic cell and insitu mapping techniques. In addition we found repeatedly significant but weaker hybridization of the beta-amyloid protein probe to the short arm of chromosome 20. 794 cells were analyzed from whole blood, lymphoblastoid and skin cultures. The latter two types of cultures had parts of the 21st chromosome translocated to other chromosomes facilitating sublocalization.

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Fine mapping of an Alzheimer Disease-associated gene encoding beta-amyloid protein

Abstract

ASJC Scopus subject areas

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