Fine genetic localization of the gene for autosomal dominant polycystic kidney disease (PKD1) with respect to physically mapped markers

Stefan Somlo, Brunhilde Wirth, Gregory G. Germino, Debra Weinstat-Saslow, Gerald A J Gillespie, Heinz Himmelbauer, Laura Steevens, Paul Coucke, Patrick Willems, Lucien Bachner, Eliecer Coto, Carlos López-Larrea, Bélen Peral, JoséLuis San Millán, Jasper J. Saris, Martijn H. Breuning, Anna Maria Frischauf, Stephen T. Reeders

Research output: Contribution to journalArticle

Abstract

PKD1, the gene for the chromosome 16-linked form of autosomal dominant polycystic kidney disease, has previously been genetically mapped to an interval bounded by the polymorphic loci Fr3-42 EKMDA2 distally and O327hb O90a proximally. More recently, 26.6PROX was identified as the closest proximal flanking locus. We set out to refine the localization of PKD1 by identifying a series of single recombination events between the flanking markers Fr3-42 EKMDA2 and O327hb O90a and analyzing them with a new set of polymorphic loci that have been physically mapped within the PKD1 interval. We identified 11 such crossovers in eight families; 6 of these fell into the interval between GGG1 and 26.6PROX, a distance of

Original languageEnglish (US)
Pages (from-to)152-158
Number of pages7
JournalGenomics
Volume13
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Autosomal Dominant Polycystic Kidney
Chromosomes, Human, Pair 16
Genetic Recombination
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Somlo, S., Wirth, B., Germino, G. G., Weinstat-Saslow, D., Gillespie, G. A. J., Himmelbauer, H., ... Reeders, S. T. (1992). Fine genetic localization of the gene for autosomal dominant polycystic kidney disease (PKD1) with respect to physically mapped markers. Genomics, 13(1), 152-158. https://doi.org/10.1016/0888-7543(92)90215-E

Fine genetic localization of the gene for autosomal dominant polycystic kidney disease (PKD1) with respect to physically mapped markers. / Somlo, Stefan; Wirth, Brunhilde; Germino, Gregory G.; Weinstat-Saslow, Debra; Gillespie, Gerald A J; Himmelbauer, Heinz; Steevens, Laura; Coucke, Paul; Willems, Patrick; Bachner, Lucien; Coto, Eliecer; López-Larrea, Carlos; Peral, Bélen; Millán, JoséLuis San; Saris, Jasper J.; Breuning, Martijn H.; Frischauf, Anna Maria; Reeders, Stephen T.

In: Genomics, Vol. 13, No. 1, 1992, p. 152-158.

Research output: Contribution to journalArticle

Somlo, S, Wirth, B, Germino, GG, Weinstat-Saslow, D, Gillespie, GAJ, Himmelbauer, H, Steevens, L, Coucke, P, Willems, P, Bachner, L, Coto, E, López-Larrea, C, Peral, B, Millán, JS, Saris, JJ, Breuning, MH, Frischauf, AM & Reeders, ST 1992, 'Fine genetic localization of the gene for autosomal dominant polycystic kidney disease (PKD1) with respect to physically mapped markers', Genomics, vol. 13, no. 1, pp. 152-158. https://doi.org/10.1016/0888-7543(92)90215-E
Somlo, Stefan ; Wirth, Brunhilde ; Germino, Gregory G. ; Weinstat-Saslow, Debra ; Gillespie, Gerald A J ; Himmelbauer, Heinz ; Steevens, Laura ; Coucke, Paul ; Willems, Patrick ; Bachner, Lucien ; Coto, Eliecer ; López-Larrea, Carlos ; Peral, Bélen ; Millán, JoséLuis San ; Saris, Jasper J. ; Breuning, Martijn H. ; Frischauf, Anna Maria ; Reeders, Stephen T. / Fine genetic localization of the gene for autosomal dominant polycystic kidney disease (PKD1) with respect to physically mapped markers. In: Genomics. 1992 ; Vol. 13, No. 1. pp. 152-158.
@article{488feeec3bb848398c16be286ac08a07,
title = "Fine genetic localization of the gene for autosomal dominant polycystic kidney disease (PKD1) with respect to physically mapped markers",
abstract = "PKD1, the gene for the chromosome 16-linked form of autosomal dominant polycystic kidney disease, has previously been genetically mapped to an interval bounded by the polymorphic loci Fr3-42 EKMDA2 distally and O327hb O90a proximally. More recently, 26.6PROX was identified as the closest proximal flanking locus. We set out to refine the localization of PKD1 by identifying a series of single recombination events between the flanking markers Fr3-42 EKMDA2 and O327hb O90a and analyzing them with a new set of polymorphic loci that have been physically mapped within the PKD1 interval. We identified 11 such crossovers in eight families; 6 of these fell into the interval between GGG1 and 26.6PROX, a distance of",
author = "Stefan Somlo and Brunhilde Wirth and Germino, {Gregory G.} and Debra Weinstat-Saslow and Gillespie, {Gerald A J} and Heinz Himmelbauer and Laura Steevens and Paul Coucke and Patrick Willems and Lucien Bachner and Eliecer Coto and Carlos L{\'o}pez-Larrea and B{\'e}len Peral and Mill{\'a}n, {Jos{\'e}Luis San} and Saris, {Jasper J.} and Breuning, {Martijn H.} and Frischauf, {Anna Maria} and Reeders, {Stephen T.}",
year = "1992",
doi = "10.1016/0888-7543(92)90215-E",
language = "English (US)",
volume = "13",
pages = "152--158",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Fine genetic localization of the gene for autosomal dominant polycystic kidney disease (PKD1) with respect to physically mapped markers

AU - Somlo, Stefan

AU - Wirth, Brunhilde

AU - Germino, Gregory G.

AU - Weinstat-Saslow, Debra

AU - Gillespie, Gerald A J

AU - Himmelbauer, Heinz

AU - Steevens, Laura

AU - Coucke, Paul

AU - Willems, Patrick

AU - Bachner, Lucien

AU - Coto, Eliecer

AU - López-Larrea, Carlos

AU - Peral, Bélen

AU - Millán, JoséLuis San

AU - Saris, Jasper J.

AU - Breuning, Martijn H.

AU - Frischauf, Anna Maria

AU - Reeders, Stephen T.

PY - 1992

Y1 - 1992

N2 - PKD1, the gene for the chromosome 16-linked form of autosomal dominant polycystic kidney disease, has previously been genetically mapped to an interval bounded by the polymorphic loci Fr3-42 EKMDA2 distally and O327hb O90a proximally. More recently, 26.6PROX was identified as the closest proximal flanking locus. We set out to refine the localization of PKD1 by identifying a series of single recombination events between the flanking markers Fr3-42 EKMDA2 and O327hb O90a and analyzing them with a new set of polymorphic loci that have been physically mapped within the PKD1 interval. We identified 11 such crossovers in eight families; 6 of these fell into the interval between GGG1 and 26.6PROX, a distance of

AB - PKD1, the gene for the chromosome 16-linked form of autosomal dominant polycystic kidney disease, has previously been genetically mapped to an interval bounded by the polymorphic loci Fr3-42 EKMDA2 distally and O327hb O90a proximally. More recently, 26.6PROX was identified as the closest proximal flanking locus. We set out to refine the localization of PKD1 by identifying a series of single recombination events between the flanking markers Fr3-42 EKMDA2 and O327hb O90a and analyzing them with a new set of polymorphic loci that have been physically mapped within the PKD1 interval. We identified 11 such crossovers in eight families; 6 of these fell into the interval between GGG1 and 26.6PROX, a distance of

UR - http://www.scopus.com/inward/record.url?scp=0026604186&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026604186&partnerID=8YFLogxK

U2 - 10.1016/0888-7543(92)90215-E

DO - 10.1016/0888-7543(92)90215-E

M3 - Article

VL - 13

SP - 152

EP - 158

JO - Genomics

JF - Genomics

SN - 0888-7543

IS - 1

ER -