Fine genetic localization of the gene for autosomal dominant polycystic kidney disease (PKD1) with respect to physically mapped markers

Stefan Somlo, Brunhilde Wirth, Gregory G. Germino, Debra Weinstat-Saslow, Gerald A J Gillespie, Heinz Himmelbauer, Laura Steevens, Paul Coucke, Patrick Willems, Lucien Bachner, Eliecer Coto, Carlos López-Larrea, Bélen Peral, JoséLuis San Millán, Jasper J. Saris, Martijn H. Breuning, Anna Maria Frischauf, Stephen T. Reeders

Research output: Contribution to journalArticle

Abstract

PKD1, the gene for the chromosome 16-linked form of autosomal dominant polycystic kidney disease, has previously been genetically mapped to an interval bounded by the polymorphic loci Fr3-42 EKMDA2 distally and O327hb O90a proximally. More recently, 26.6PROX was identified as the closest proximal flanking locus. We set out to refine the localization of PKD1 by identifying a series of single recombination events between the flanking markers Fr3-42 EKMDA2 and O327hb O90a and analyzing them with a new set of polymorphic loci that have been physically mapped within the PKD1 interval. We identified 11 such crossovers in eight families; 6 of these fell into the interval between GGG1 and 26.6PROX, a distance of

Original languageEnglish (US)
Pages (from-to)152-158
Number of pages7
JournalGenomics
Volume13
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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    Somlo, S., Wirth, B., Germino, G. G., Weinstat-Saslow, D., Gillespie, G. A. J., Himmelbauer, H., Steevens, L., Coucke, P., Willems, P., Bachner, L., Coto, E., López-Larrea, C., Peral, B., Millán, J. S., Saris, J. J., Breuning, M. H., Frischauf, A. M., & Reeders, S. T. (1992). Fine genetic localization of the gene for autosomal dominant polycystic kidney disease (PKD1) with respect to physically mapped markers. Genomics, 13(1), 152-158. https://doi.org/10.1016/0888-7543(92)90215-E