TY - JOUR
T1 - Fine genetic localization of the gene for autosomal dominant polycystic kidney disease (PKD1) with respect to physically mapped markers
AU - Somlo, Stefan
AU - Wirth, Brunhilde
AU - Germino, Gregory G.
AU - Weinstat-Saslow, Debra
AU - Gillespie, Gerald A J
AU - Himmelbauer, Heinz
AU - Steevens, Laura
AU - Coucke, Paul
AU - Willems, Patrick
AU - Bachner, Lucien
AU - Coto, Eliecer
AU - López-Larrea, Carlos
AU - Peral, Bélen
AU - Millán, JoséLuis San
AU - Saris, Jasper J.
AU - Breuning, Martijn H.
AU - Frischauf, Anna Maria
AU - Reeders, Stephen T.
PY - 1992
Y1 - 1992
N2 - PKD1, the gene for the chromosome 16-linked form of autosomal dominant polycystic kidney disease, has previously been genetically mapped to an interval bounded by the polymorphic loci Fr3-42 EKMDA2 distally and O327hb O90a proximally. More recently, 26.6PROX was identified as the closest proximal flanking locus. We set out to refine the localization of PKD1 by identifying a series of single recombination events between the flanking markers Fr3-42 EKMDA2 and O327hb O90a and analyzing them with a new set of polymorphic loci that have been physically mapped within the PKD1 interval. We identified 11 such crossovers in eight families; 6 of these fell into the interval between GGG1 and 26.6PROX, a distance of
AB - PKD1, the gene for the chromosome 16-linked form of autosomal dominant polycystic kidney disease, has previously been genetically mapped to an interval bounded by the polymorphic loci Fr3-42 EKMDA2 distally and O327hb O90a proximally. More recently, 26.6PROX was identified as the closest proximal flanking locus. We set out to refine the localization of PKD1 by identifying a series of single recombination events between the flanking markers Fr3-42 EKMDA2 and O327hb O90a and analyzing them with a new set of polymorphic loci that have been physically mapped within the PKD1 interval. We identified 11 such crossovers in eight families; 6 of these fell into the interval between GGG1 and 26.6PROX, a distance of
UR - http://www.scopus.com/inward/record.url?scp=0026604186&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026604186&partnerID=8YFLogxK
U2 - 10.1016/0888-7543(92)90215-E
DO - 10.1016/0888-7543(92)90215-E
M3 - Article
C2 - 1349570
AN - SCOPUS:0026604186
SN - 0888-7543
VL - 13
SP - 152
EP - 158
JO - Genomics
JF - Genomics
IS - 1
ER -