Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33

Y. S. Chen; N. Akula; S. D. Detera-Wadleigh; T. G. Schulze; J. Thomas; J. B. Potash; J. R. DePaulo; M. G. McInnis; N. J. Cox; F. J. McMahon

Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33

Y. S. Chen, N. Akula, S. D. Detera-Wadleigh, T. G. Schulze, J. Thomas, J. B. Potash, J. R. DePaulo, M. G. McInnis, N. J. Cox, F. J. McMahon

School of Medicine

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Previous studies have implicated the genes G72 and G30, on chromosome 13q33, in both schizophrenia and bipolar disorder. In this issue, Chen et al show that the reported association between bipolar disorder and markers near these genes can be reproduced in an independent sample. The new findings involve different alleles than those reported previously, suggesting a complex relationship between disease and genetic variation at this locus. Further studies are needed to identify variants that alter function and modify disease risk.

Original language	English (US)
Pages (from-to)	5+3
Journal	Molecular psychiatry
Volume	9
Issue number	1
State	Published - 2004

ASJC Scopus subject areas

Psychiatry and Mental health
Cellular and Molecular Neuroscience
Molecular Biology

Cite this

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title = "Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33",

abstract = "Previous studies have implicated the genes G72 and G30, on chromosome 13q33, in both schizophrenia and bipolar disorder. In this issue, Chen et al show that the reported association between bipolar disorder and markers near these genes can be reproduced in an independent sample. The new findings involve different alleles than those reported previously, suggesting a complex relationship between disease and genetic variation at this locus. Further studies are needed to identify variants that alter function and modify disease risk.",

author = "Chen, {Y. S.} and N. Akula and Detera-Wadleigh, {S. D.} and Schulze, {T. G.} and J. Thomas and Potash, {J. B.} and DePaulo, {J. R.} and McInnis, {M. G.} and Cox, {N. J.} and McMahon, {F. J.}",

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AU - Chen, Y. S.

AU - Akula, N.

AU - Detera-Wadleigh, S. D.

AU - Schulze, T. G.

AU - Thomas, J.

AU - Potash, J. B.

AU - DePaulo, J. R.

AU - McInnis, M. G.

AU - Cox, N. J.

AU - McMahon, F. J.

PY - 2004

Y1 - 2004

N2 - Previous studies have implicated the genes G72 and G30, on chromosome 13q33, in both schizophrenia and bipolar disorder. In this issue, Chen et al show that the reported association between bipolar disorder and markers near these genes can be reproduced in an independent sample. The new findings involve different alleles than those reported previously, suggesting a complex relationship between disease and genetic variation at this locus. Further studies are needed to identify variants that alter function and modify disease risk.

AB - Previous studies have implicated the genes G72 and G30, on chromosome 13q33, in both schizophrenia and bipolar disorder. In this issue, Chen et al show that the reported association between bipolar disorder and markers near these genes can be reproduced in an independent sample. The new findings involve different alleles than those reported previously, suggesting a complex relationship between disease and genetic variation at this locus. Further studies are needed to identify variants that alter function and modify disease risk.

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Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33

Abstract

ASJC Scopus subject areas

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