TY - JOUR
T1 - Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33
AU - Chen, Y. S.
AU - Akula, N.
AU - Detera-Wadleigh, S. D.
AU - Schulze, T. G.
AU - Thomas, J.
AU - Potash, James Bennett
AU - DePaulo, J. R.
AU - Mcinnis, Melvin
AU - Cox, N. J.
AU - McMahon, Francis Joseph
N1 - Funding Information:
This study was supported in part by Young Investigator Awards from the National Association for Research on Schizophrenia and Depression (Y-SC and TGS) and by the National Institute of Mental Health Intramural Research Program (FJM and SDD). Sample collection was supported by grants from the National Institute of Mental Health, The Charles A Dana Foundation, and the Ted and Vada Stanley Foundation. We thank Elliot S Gershon for kindly making his manuscript available to us in advance of publication; Sylvia G Simpson, Dean F MacKinnon, and Susan Folstein for contributing to the clinical assessments and diagnoses; Tu Nguyen for assisting with data management; and the family volunteers, without whom this work would not have been possible.
PY - 2004
Y1 - 2004
N2 - Markers near the nested genes G72 and G30 on chromosome 13q33 have been implicated in the etiology of schizophrenia and, recently, bipolar affective disorder (BPAD). Hattori et al (2003) reported that single-nucleotide polymorphisms (SNPs) near the G72/G30 locus were associated with BPAD in a sample of 22 pedigrees, and that SNP haplotypes were associated in a second, larger sample of triads. The present study attempts to replicate this finding in an independent case-control sample. Six SNPs near the G72/G30 locus, including the most strongly associated markers in the previous study, were tested in 139 cases and 113 ethnically matched controls. Significant association was detected between BPAD and two adjacent SNPs (smallest P=0.007; global P=0.024). Haplotype analysis produced additional support for association (smallest P=0.004; global P=0.004). Analysis of 31 unlinked microsatellite markers detected no population stratification in the cases or controls studied. Although the associated alleles and haplotypes differ from those previously reported, these new results provide further evidence, in an independent sample, for an association between BPAD and genetic variation in the vicinity of the genes G72 and G30.
AB - Markers near the nested genes G72 and G30 on chromosome 13q33 have been implicated in the etiology of schizophrenia and, recently, bipolar affective disorder (BPAD). Hattori et al (2003) reported that single-nucleotide polymorphisms (SNPs) near the G72/G30 locus were associated with BPAD in a sample of 22 pedigrees, and that SNP haplotypes were associated in a second, larger sample of triads. The present study attempts to replicate this finding in an independent case-control sample. Six SNPs near the G72/G30 locus, including the most strongly associated markers in the previous study, were tested in 139 cases and 113 ethnically matched controls. Significant association was detected between BPAD and two adjacent SNPs (smallest P=0.007; global P=0.024). Haplotype analysis produced additional support for association (smallest P=0.004; global P=0.004). Analysis of 31 unlinked microsatellite markers detected no population stratification in the cases or controls studied. Although the associated alleles and haplotypes differ from those previously reported, these new results provide further evidence, in an independent sample, for an association between BPAD and genetic variation in the vicinity of the genes G72 and G30.
KW - Allele frequency
KW - Genetics
KW - Mood disorder
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U2 - 10.1038/sj.mp.4001453
DO - 10.1038/sj.mp.4001453
M3 - Article
C2 - 14699445
AN - SCOPUS:0842264955
SN - 1359-4184
VL - 9
SP - 87
EP - 92
JO - Molecular Psychiatry
JF - Molecular Psychiatry
IS - 1
ER -