TY - GEN
T1 - Finding the optimal compression level for Strain-Encoded (SENC) breast MRI; simulations and phantom experiments
AU - Harouni, Ahmed A.
AU - Jacobs, Michael A.
AU - Osman, Nael F.
PY - 2011
Y1 - 2011
N2 - Breast cancer is the most common cancer among women and the second highest cause of cancer-related death. Diagnostic magnetic resonance imaging (MRI) is recommended to screen high-risk patients. Strain-Encoded (SENC) can improve MRI's specificity by detecting and differentiating masses according to their stiffness. Previous phantom and ex-vivo studies have utilized SENC to detect cancerous masses. However, SENC required a 30% compression of the tissue, which may not be feasible for in-vivo imaging. In this work, we use finite element method simulations and phantom experiments to determine the minimum compression required to detect and classify masses. Results show that SENC is capable of detecting stiff masses at compression level of 7%, though higher compression is needed in order to differentiate between normal tissue and benign or malignant masses. With on-line SENC calculations implemented on the scanner console, we propose to start with small compressions for maximum patient comfort, then progress to larger compressions if any masses are detected.
AB - Breast cancer is the most common cancer among women and the second highest cause of cancer-related death. Diagnostic magnetic resonance imaging (MRI) is recommended to screen high-risk patients. Strain-Encoded (SENC) can improve MRI's specificity by detecting and differentiating masses according to their stiffness. Previous phantom and ex-vivo studies have utilized SENC to detect cancerous masses. However, SENC required a 30% compression of the tissue, which may not be feasible for in-vivo imaging. In this work, we use finite element method simulations and phantom experiments to determine the minimum compression required to detect and classify masses. Results show that SENC is capable of detecting stiff masses at compression level of 7%, though higher compression is needed in order to differentiate between normal tissue and benign or malignant masses. With on-line SENC calculations implemented on the scanner console, we propose to start with small compressions for maximum patient comfort, then progress to larger compressions if any masses are detected.
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U2 - 10.1007/978-3-642-23623-5_56
DO - 10.1007/978-3-642-23623-5_56
M3 - Conference contribution
C2 - 22003648
AN - SCOPUS:82255181790
SN - 9783642236228
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 444
EP - 451
BT - Medical Image Computing and Computer-Assisted Intervention, MICCAI 2011 - 14th International Conference, Proceedings
T2 - 14th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2011
Y2 - 18 September 2011 through 22 September 2011
ER -