Filament assemblies in foreign nucleic acid sensors

Jungsan Sohn, Sun Hur

Research output: Contribution to journalReview article

Abstract

Helical filamentous assembly is ubiquitous in biology, but was only recently realized to be broadly employed in the innate immune system of vertebrates. Accumulating evidence suggests that the filamentous assemblies and helical oligomerization play important roles in detection of foreign nucleic acids and activation of the signaling pathways to produce antiviral and inflammatory mediators. In this review, we focus on the helical assemblies observed in the signaling pathways of RIG-I-like receptors (RLRs) and AIM2-like receptors (ALRs). We describe ligand-dependent oligomerization of receptor, receptor-dependent oligomerization of signaling adaptor molecules, and their functional implications and regulations.

Original languageEnglish (US)
Pages (from-to)134-144
Number of pages11
JournalCurrent Opinion in Structural Biology
Volume37
DOIs
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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