TY - JOUR
T1 - Figural memory performance and functional magnetic resonance imaging activity across the adult lifespan
AU - Jamadar, Sharna
AU - Assaf, Michal
AU - Jagannathan, Kanchana
AU - Anderson, Karen
AU - Pearlson, Godfrey D.
N1 - Funding Information:
This work was supported by NIMH 1 RO1 MH074797 (Pearlson) Schizophrenia: Memory, Genes and fMRI.
PY - 2013/1
Y1 - 2013/1
N2 - We examined performance and functional magnetic resonance imaging activity in participants (n = 235) aged 17-81 years on a nonverbal recognition memory task, figural memory. Reaction time, error rate, and response bias measures indicated that the youngest and oldest participants were faster, made fewer errors, and showed a more conservative response bias than participants in the median age ranges. Encoding and Recognition phases activated a distributed bilateral network encompassing prefrontal, subcortical, lateral, and medial temporal and occipital regions. Activation during Encoding phase did not correlate with age. During Recognition, task-related activation for correctly identified targets (Hit-Targets) correlated linearly positively with age; nontask related activity correlated negative quadratically with age. During correctly identified distractors (Hit-Distractors) activity in task-related regions correlated positive linearly with age, nontask activity showed positive and negative quadratic relationships with age. Missed-Targets activity did not correlate with age. We concluded that figural memory performance and functional magnetic resonance imaging activity during Recognition but not Encoding was affected both by continued maturation of the brain in the early 20s and compensatory recruitment of additional brain regions during recognition memory in old age.
AB - We examined performance and functional magnetic resonance imaging activity in participants (n = 235) aged 17-81 years on a nonverbal recognition memory task, figural memory. Reaction time, error rate, and response bias measures indicated that the youngest and oldest participants were faster, made fewer errors, and showed a more conservative response bias than participants in the median age ranges. Encoding and Recognition phases activated a distributed bilateral network encompassing prefrontal, subcortical, lateral, and medial temporal and occipital regions. Activation during Encoding phase did not correlate with age. During Recognition, task-related activation for correctly identified targets (Hit-Targets) correlated linearly positively with age; nontask related activity correlated negative quadratically with age. During correctly identified distractors (Hit-Distractors) activity in task-related regions correlated positive linearly with age, nontask activity showed positive and negative quadratic relationships with age. Missed-Targets activity did not correlate with age. We concluded that figural memory performance and functional magnetic resonance imaging activity during Recognition but not Encoding was affected both by continued maturation of the brain in the early 20s and compensatory recruitment of additional brain regions during recognition memory in old age.
KW - FMRI
KW - Figural memory
KW - Healthy aging
KW - Nonverbal memory
UR - http://www.scopus.com/inward/record.url?scp=84868107081&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84868107081&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2012.07.013
DO - 10.1016/j.neurobiolaging.2012.07.013
M3 - Article
C2 - 22901696
AN - SCOPUS:84868107081
SN - 0197-4580
VL - 34
SP - 110
EP - 127
JO - Neurobiology of aging
JF - Neurobiology of aging
IS - 1
ER -