TY - JOUR
T1 - Fifteen-year mortality of patients with asthma–COPD overlap syndrome
AU - Sorino, Claudio
AU - Pedone, Claudio
AU - Scichilone, Nicola
N1 - Funding Information:
The study was supported by the Italian Association for the Prevention, Diagnosis, and Treatment of Respiratory Diseases (PreDiCARe).
Publisher Copyright:
© 2016 European Federation of Internal Medicine.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Background The coexistence of asthma and chronic obstructive pulmonary disease (asthma–COPD overlap syndrome: ACOS) is increasingly recognized but data about its prevalence and long-term mortality are needed. Methods Prevalence of ACOS and 15-year mortality rates were assessed in 1065 subjects aged > 65 years, enrolled in the SA.R.A. study, with complete clinical, lung functional and follow-up data. Physical performance, disease-related disability, and health-related quality of life (HRQL) were also evaluated. Results ACOS was found in 11.1% of subjects (29.4% of those previously diagnosed with COPD and 19.7% of those with asthma). ACOS was positively associated with impaired physical performance, functional ability, and HRQL. Individuals with ACOS had higher mortality rates than controls (7.17 per 100 person-years; mortality rate ratio: 1.83). After adjustment for the main confounders, the risk of all-cause mortality remained significantly increased in subjects with ACOS (HR: 1.82), COPD (HR: 2.12), and restriction (HR: 2.41), but not asthma. Conclusions Long-term prognosis of ACOS was similar to COPD, and worse than asthma and healthy controls. ACOS had a significant impact on physical performance, functional ability, and HRQL.
AB - Background The coexistence of asthma and chronic obstructive pulmonary disease (asthma–COPD overlap syndrome: ACOS) is increasingly recognized but data about its prevalence and long-term mortality are needed. Methods Prevalence of ACOS and 15-year mortality rates were assessed in 1065 subjects aged > 65 years, enrolled in the SA.R.A. study, with complete clinical, lung functional and follow-up data. Physical performance, disease-related disability, and health-related quality of life (HRQL) were also evaluated. Results ACOS was found in 11.1% of subjects (29.4% of those previously diagnosed with COPD and 19.7% of those with asthma). ACOS was positively associated with impaired physical performance, functional ability, and HRQL. Individuals with ACOS had higher mortality rates than controls (7.17 per 100 person-years; mortality rate ratio: 1.83). After adjustment for the main confounders, the risk of all-cause mortality remained significantly increased in subjects with ACOS (HR: 1.82), COPD (HR: 2.12), and restriction (HR: 2.41), but not asthma. Conclusions Long-term prognosis of ACOS was similar to COPD, and worse than asthma and healthy controls. ACOS had a significant impact on physical performance, functional ability, and HRQL.
KW - Asthma
KW - COPD
KW - Chronic obstructive pulmonary disease
KW - Epidemiology
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U2 - 10.1016/j.ejim.2016.06.020
DO - 10.1016/j.ejim.2016.06.020
M3 - Article
C2 - 27357368
AN - SCOPUS:84992456250
SN - 0953-6205
VL - 34
SP - 72
EP - 77
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
ER -