Fifteen-year mortality of patients with asthma–COPD overlap syndrome

Claudio Sorino, Claudio Pedone, Nicola Scichilone

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background The coexistence of asthma and chronic obstructive pulmonary disease (asthma–COPD overlap syndrome: ACOS) is increasingly recognized but data about its prevalence and long-term mortality are needed. Methods Prevalence of ACOS and 15-year mortality rates were assessed in 1065 subjects aged > 65 years, enrolled in the SA.R.A. study, with complete clinical, lung functional and follow-up data. Physical performance, disease-related disability, and health-related quality of life (HRQL) were also evaluated. Results ACOS was found in 11.1% of subjects (29.4% of those previously diagnosed with COPD and 19.7% of those with asthma). ACOS was positively associated with impaired physical performance, functional ability, and HRQL. Individuals with ACOS had higher mortality rates than controls (7.17 per 100 person-years; mortality rate ratio: 1.83). After adjustment for the main confounders, the risk of all-cause mortality remained significantly increased in subjects with ACOS (HR: 1.82), COPD (HR: 2.12), and restriction (HR: 2.41), but not asthma. Conclusions Long-term prognosis of ACOS was similar to COPD, and worse than asthma and healthy controls. ACOS had a significant impact on physical performance, functional ability, and HRQL.

Original languageEnglish (US)
Pages (from-to)72-77
Number of pages6
JournalEuropean Journal of Internal Medicine
StatePublished - Oct 1 2016


  • Asthma
  • COPD
  • Chronic obstructive pulmonary disease
  • Epidemiology

ASJC Scopus subject areas

  • Internal Medicine


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