Fifteen non-CODIS autosomal short tandem repeat loci multiplex data from nine population groups living in Taiwan

Hsiao Lin Hwa, Yih Yuan Chang, James Chun I Lee, Chun Yen Lin, Hsiang Yi Yin, Li Hui Tseng, Yi Ning Su, Tsang Ming Ko

Research output: Contribution to journalArticlepeer-review

Abstract

The analysis of autosomal short tandem repeat (STR) loci is a powerful tool in forensic genetics. We developed a multiplex system in which 15 non-Combined DNA Index System autosomal STRs (D3S1744, D4S2366, D8S1110, D10S2325, D12S1090, D13S765, D14S608, Penta E, D17S1294, D18S536, D18S1270, D20S470, D21S1437, Penta D, and D22S683) could be amplified in one single polymerase chain reaction. DNA samples from 1,098 unrelated subjects of nine population groups living in Taiwan, including Taiwanese Han, indigenous Taiwanese of Taiwan Island, Tao, mainland Chinese, Filipinos, Thais, Vietnamese, Indonesians, and Caucasians, were collected and analyzed using this system. The distributions of the allelic frequencies and the forensic parameters of each population group were presented. The combined discrimination power and the combined power of exclusion were high in all population groups tested in this study. A multidimensional scaling plot of these nine population groups based on the Reynolds' genetic distances calculated from 15 autosomal STRs was constructed, and the genetic substructure in this area was presented. In conclusion, this 15 autosomal STR multiplex system provides highly informative STR data and appears useful in forensic casework and parentage testing in different populations.

Original languageEnglish (US)
Pages (from-to)671-675
Number of pages5
JournalInternational Journal of Legal Medicine
Volume126
Issue number4
DOIs
StatePublished - Jul 2012
Externally publishedYes

Keywords

  • Autosomal short tandem repeats
  • Discrimination power
  • Forensic genetics
  • Multiplex polymerase chain reaction system

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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