Field trials of monovalent Ogawa and Inaba cholera vaccines in rural Bangladesh. Three years of observation

W. H. Mosley, K. M.A. Aziz, A. S.M. Mizanur Rahman, A. K. Chowdhury, A. Ahmed

Research output: Contribution to journalArticle

Abstract

A controlled cholera vaccine field trial was carried out to test the efficacy of monovalent whole cell Inaba and Ogawa cholera vaccines and a purified Inaba antigen. This study was designed particularly to study the level of protection produced by these vaccines against homologous and heterologous serotypes and to correlate the results with mouse protection tests and human serological response to the vaccines. A cohort of 45,000 children, aged 0-14 yr, was divided into a control group and 3 vaccine groups. Inoculations were given annually for 2 yr just before the start of the cholera season, and followup was continued for one additional yr. Essentially, all cholera cases were due to the Inaba serotype, so that protection could be studied only against that serotype. Two annual injections of the whole cell Inaba vaccine gave the highest level of protection, averaging 84% over the 3 yr of followup; a single injection of the purified Inaba vaccine gave less protection (51%). Two annual injections of the whole cell Ogawa vaccine failed to protect childen under the age of 5 but did produce 48% protection for children children 5-14 against Inaba cholera. Serological surveys correlated poorly with protection; specifically, the Ogawa vaccine produced high anti Inaba titres in young children but no protection. The cross protection against Inaba cholera produced by Ogawa vaccine in the older children is assumed to be due to boosting of naturally acquired immunity in this population. Monovalent vaccine connot be recommanded for general public health use because of the serotype specificity of protection that this study demonstrated.

Original languageEnglish (US)
Pages (from-to)381-387
Number of pages7
JournalBulletin of the World Health Organization
Volume49
Issue number4
StatePublished - Dec 1 1973

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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