Field trial of oral cholera vaccines in Bangladesh: Results of one year of follow-up

J. D. Clemens; J. R. Harris; D. A. Sack; J. Chakraborty; F. Ahmed; B. F. Stanton; M. U. Khan; B. A. Kay; N. Huda; M. R. Khan; M. Yunus; M. R. Rao; A. M. Svennerholm; J. Holmgren

doi:10.1093/infdis/158.1.60

Field trial of oral cholera vaccines in Bangladesh: Results of one year of follow-up

J. D. Clemens, J. R. Harris, D. A. Sack, J. Chakraborty, F. Ahmed, B. F. Stanton, M. U. Khan, B. A. Kay, N. Huda, M. R. Khan, M. Yunus, M. R. Rao, A. M. Svennerholm, J. Holmgren

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113 Scopus citations

Abstract

We assessed the protective efficacy (PE) of three doses of B subunit-killed whole cell (BS-WC) and killed whole cell-only (WC) oral cholera vaccines in a randomized, double-blind trial among 62,285 children and women residing in rural Bangladesh. After one complete year of surveillance, 110 cases of cholera were detected in the placebo group, 52 in the WC group (PE, 53%; P < .0001), and 41 in the BS-WC group (PE, 62%; P< .0001). Protection was greater for BS-WC recipients than for WC recipients only during the initial eight months of observation. Both vaccines conferred equivalent protection against cholera associated with life-threatening dehydration and against less severe cholera. High-grade, sustained protection was observed in persons vaccinated when older than five years; in younger persons protection was transient. We conclude that BS-WC and WC vaccines confer significant protection against cholera, particularly in persons vaccinated when older than five years.

Original language	English (US)
Pages (from-to)	60-69
Number of pages	10
Journal	Journal of Infectious Diseases
Volume	158
Issue number	1
DOIs	https://doi.org/10.1093/infdis/158.1.60
State	Published - 1988
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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Clemens, J. D., Harris, J. R., Sack, D. A., Chakraborty, J., Ahmed, F., Stanton, B. F., Khan, M. U., Kay, B. A., Huda, N., Khan, M. R., Yunus, M., Rao, M. R., Svennerholm, A. M., & Holmgren, J. (1988). Field trial of oral cholera vaccines in Bangladesh: Results of one year of follow-up. Journal of Infectious Diseases, 158(1), 60-69. https://doi.org/10.1093/infdis/158.1.60

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title = "Field trial of oral cholera vaccines in Bangladesh: Results of one year of follow-up",

abstract = "We assessed the protective efficacy (PE) of three doses of B subunit-killed whole cell (BS-WC) and killed whole cell-only (WC) oral cholera vaccines in a randomized, double-blind trial among 62,285 children and women residing in rural Bangladesh. After one complete year of surveillance, 110 cases of cholera were detected in the placebo group, 52 in the WC group (PE, 53%; P < .0001), and 41 in the BS-WC group (PE, 62%; P< .0001). Protection was greater for BS-WC recipients than for WC recipients only during the initial eight months of observation. Both vaccines conferred equivalent protection against cholera associated with life-threatening dehydration and against less severe cholera. High-grade, sustained protection was observed in persons vaccinated when older than five years; in younger persons protection was transient. We conclude that BS-WC and WC vaccines confer significant protection against cholera, particularly in persons vaccinated when older than five years.",

author = "Clemens, {J. D.} and Harris, {J. R.} and Sack, {D. A.} and J. Chakraborty and F. Ahmed and Stanton, {B. F.} and Khan, {M. U.} and Kay, {B. A.} and N. Huda and Khan, {M. R.} and M. Yunus and Rao, {M. R.} and Svennerholm, {A. M.} and J. Holmgren",

note = "Funding Information: This work was supported by funds from the U.S. Agency for International Development, the government of Japan, the Swedish Agency for Research Cooperation with Developing Countries, and the World Health Organization.",

year = "1988",

doi = "10.1093/infdis/158.1.60",

language = "English (US)",

volume = "158",

pages = "60--69",

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T1 - Field trial of oral cholera vaccines in Bangladesh

T2 - Results of one year of follow-up

AU - Clemens, J. D.

AU - Harris, J. R.

AU - Sack, D. A.

AU - Chakraborty, J.

AU - Ahmed, F.

AU - Stanton, B. F.

AU - Khan, M. U.

AU - Kay, B. A.

AU - Huda, N.

AU - Khan, M. R.

AU - Yunus, M.

AU - Rao, M. R.

AU - Svennerholm, A. M.

AU - Holmgren, J.

N1 - Funding Information: This work was supported by funds from the U.S. Agency for International Development, the government of Japan, the Swedish Agency for Research Cooperation with Developing Countries, and the World Health Organization.

PY - 1988

Y1 - 1988

N2 - We assessed the protective efficacy (PE) of three doses of B subunit-killed whole cell (BS-WC) and killed whole cell-only (WC) oral cholera vaccines in a randomized, double-blind trial among 62,285 children and women residing in rural Bangladesh. After one complete year of surveillance, 110 cases of cholera were detected in the placebo group, 52 in the WC group (PE, 53%; P < .0001), and 41 in the BS-WC group (PE, 62%; P< .0001). Protection was greater for BS-WC recipients than for WC recipients only during the initial eight months of observation. Both vaccines conferred equivalent protection against cholera associated with life-threatening dehydration and against less severe cholera. High-grade, sustained protection was observed in persons vaccinated when older than five years; in younger persons protection was transient. We conclude that BS-WC and WC vaccines confer significant protection against cholera, particularly in persons vaccinated when older than five years.

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Field trial of oral cholera vaccines in Bangladesh: Results of one year of follow-up

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