Abstract
The protective efficacy (PE) of B subunit killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines was assessed in a randomised double-blind field trial among children aged 2-15 years and women over 15 years in rural Bangladesh. Among the 62 285 subjects who received three doses of BS-WC, WC, or Escherichia coli K12 strain placebo, cumulative PE at 3 years of follow-up was 50% for BS-WC and 52% for WC. PE was similar against severe and non-severe cholera, but was significantly lower in children who were vaccinated at 2-5 years (26% for BS-WC; 23% for WC) than in older persons (63% for BS-WC; 68% for WC). Among persons vaccinated at 2-5 years, protection at 4-6 months of follow-up was similar to that for older persons, but rapidly waned thereafter and was not evident during the third year of follow-up. In contrast, persons vaccinated at older ages were protected even in the third year of follow-up (PE 40% for BS-WC; 62% for WC). PE was substantially higher against classical cholera (58% for BS-WC; 60% for WC) than against El Tor cholera (39% and 40%).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 270-273 |
| Number of pages | 4 |
| Journal | The Lancet |
| Volume | 335 |
| Issue number | 8684 |
| DOIs | |
| State | Published - Feb 3 1990 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
Field trial of oral cholera vaccines in Bangladesh : results from three-year follow-up. / Clemens, J. D.; Sack, D. A.; Harris, J. R.; van Loon, F.; Chakraborty, J.; Ahmed, F.; Rao, M. R.; Khan, M. R.; Yunus, Md; Huda, N.; Stanton, B. F.; Kay, B. A.; Eeckels, R.; Clemens, J. D.; Rao, M. R.; Kay, B. A.; Sack, D. A.; Harris, J. R.; Stanton, B. F.; Walter, S.; Eeckels, R.; Svennerholm, A. M.; Holmgren, J.
In: The Lancet, Vol. 335, No. 8684, 03.02.1990, p. 270-273.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Field trial of oral cholera vaccines in Bangladesh
T2 - results from three-year follow-up
AU - Clemens, J. D.
AU - Sack, D. A.
AU - Harris, J. R.
AU - van Loon, F.
AU - Chakraborty, J.
AU - Ahmed, F.
AU - Rao, M. R.
AU - Khan, M. R.
AU - Yunus, Md
AU - Huda, N.
AU - Stanton, B. F.
AU - Kay, B. A.
AU - Eeckels, R.
AU - Clemens, J. D.
AU - Rao, M. R.
AU - Kay, B. A.
AU - Sack, D. A.
AU - Harris, J. R.
AU - Stanton, B. F.
AU - Walter, S.
AU - Eeckels, R.
AU - Svennerholm, A. M.
AU - Holmgren, J.
PY - 1990/2/3
Y1 - 1990/2/3
N2 - The protective efficacy (PE) of B subunit killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines was assessed in a randomised double-blind field trial among children aged 2-15 years and women over 15 years in rural Bangladesh. Among the 62 285 subjects who received three doses of BS-WC, WC, or Escherichia coli K12 strain placebo, cumulative PE at 3 years of follow-up was 50% for BS-WC and 52% for WC. PE was similar against severe and non-severe cholera, but was significantly lower in children who were vaccinated at 2-5 years (26% for BS-WC; 23% for WC) than in older persons (63% for BS-WC; 68% for WC). Among persons vaccinated at 2-5 years, protection at 4-6 months of follow-up was similar to that for older persons, but rapidly waned thereafter and was not evident during the third year of follow-up. In contrast, persons vaccinated at older ages were protected even in the third year of follow-up (PE 40% for BS-WC; 62% for WC). PE was substantially higher against classical cholera (58% for BS-WC; 60% for WC) than against El Tor cholera (39% and 40%).
AB - The protective efficacy (PE) of B subunit killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines was assessed in a randomised double-blind field trial among children aged 2-15 years and women over 15 years in rural Bangladesh. Among the 62 285 subjects who received three doses of BS-WC, WC, or Escherichia coli K12 strain placebo, cumulative PE at 3 years of follow-up was 50% for BS-WC and 52% for WC. PE was similar against severe and non-severe cholera, but was significantly lower in children who were vaccinated at 2-5 years (26% for BS-WC; 23% for WC) than in older persons (63% for BS-WC; 68% for WC). Among persons vaccinated at 2-5 years, protection at 4-6 months of follow-up was similar to that for older persons, but rapidly waned thereafter and was not evident during the third year of follow-up. In contrast, persons vaccinated at older ages were protected even in the third year of follow-up (PE 40% for BS-WC; 62% for WC). PE was substantially higher against classical cholera (58% for BS-WC; 60% for WC) than against El Tor cholera (39% and 40%).
UR - http://www.scopus.com/inward/record.url?scp=0025157072&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025157072&partnerID=8YFLogxK
U2 - 10.1016/0140-6736(90)90080-O
DO - 10.1016/0140-6736(90)90080-O
M3 - Article
C2 - 1967730
AN - SCOPUS:0025157072
VL - 335
SP - 270
EP - 273
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 8684
ER -