Field trial of oral cholera vaccines in Bangladesh: results from three-year follow-up

J. D. Clemens, D. A. Sack, J. R. Harris, F. van Loon, J. Chakraborty, F. Ahmed, M. R. Rao, M. R. Khan, Md Yunus, N. Huda, B. F. Stanton, B. A. Kay, R. Eeckels, J. D. Clemens, M. R. Rao, B. A. Kay, D. A. Sack, J. R. Harris, B. F. Stanton, S. WalterR. Eeckels, A. M. Svennerholm, J. Holmgren

Research output: Contribution to journalArticlepeer-review

352 Scopus citations


The protective efficacy (PE) of B subunit killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines was assessed in a randomised double-blind field trial among children aged 2-15 years and women over 15 years in rural Bangladesh. Among the 62 285 subjects who received three doses of BS-WC, WC, or Escherichia coli K12 strain placebo, cumulative PE at 3 years of follow-up was 50% for BS-WC and 52% for WC. PE was similar against severe and non-severe cholera, but was significantly lower in children who were vaccinated at 2-5 years (26% for BS-WC; 23% for WC) than in older persons (63% for BS-WC; 68% for WC). Among persons vaccinated at 2-5 years, protection at 4-6 months of follow-up was similar to that for older persons, but rapidly waned thereafter and was not evident during the third year of follow-up. In contrast, persons vaccinated at older ages were protected even in the third year of follow-up (PE 40% for BS-WC; 62% for WC). PE was substantially higher against classical cholera (58% for BS-WC; 60% for WC) than against El Tor cholera (39% and 40%).

Original languageEnglish (US)
Pages (from-to)270-273
Number of pages4
JournalThe Lancet
Issue number8684
StatePublished - Feb 3 1990
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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