@article{900ceafcf5c14f5f89de592509ccfd07,
title = "FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH",
abstract = "The protective efficacy of oral B subunit killed whole-cell (BS-WC) and killed whole-cell (WC) cholera vaccines was assessed in 63 498 Bangladeshi children aged 2-15 years and women aged over 15 years. Each received three doses of BS-WC, WC, or placebo in a randomised, double-blinded fashion. Surveillance for cases seeking medical care up to six months after the third dose revealed 26 cases of confirmed cholera in the placebo group, 4 cases in the BS-WC group (protective efficacy 85%; p<0·0001), and 11 cases in the WC group (protective efficacy 58%; p<0·01). For each vaccine protective efficacy was consistent in different age-groups (2-10 years versus >10 years) and for different severities of cholera.",
author = "Clemens, {John D.} and Harris, {Jeffrey R.} and Khan, {M. R.} and Kay, {Bradford A.} and Md Yunus and Svennerholm, {Ann Mari} and Sack, {David A.} and J. Chakraborty and Stanton, {Bonita F.} and Khan, {M. U.} and William Atkinson and Jan Holmgren",
note = "Funding Information: We gratefully acknowledge the technical assistance and support of Dr F. Ahmed, M. Ali, M. Ansaruzzaman, Arabinda Banik, Shahnar Choudhury, Dr M. Giasshuddin, Moqbul Hossain, Dr Anwarul Huq, Dr N. Huda,A. K. M. Nurul Islam, M. A. H. Miah, M. A. Sattar Miah, Liaquat Mondal, Md Noorullah, Badrul Prodhan, Anisur Rahaman, Rezaur Rahman, Siddiqur Rahman, A. M. Sarder, K. Shaikh, and the additional 407 field, laboratory, and data management staff who worked so diligently. Dr Michael Merson, Dr Henry Mosley, Dr Nathaniel Pierce, Dr Stephen Walter, Alistair Wiley and Dr Bogdan Wojtyniak provided helpful advice for the design and analysis of the study. Dr Ivan Ciznar, Dr Roger Eeckets, and Dr William B. Greenough gave support and encouragement. Rita Ramos provided secretarial help. Institut Merieux, Lyon, France, in collaboration with the National Bacteriology Laboratory, Stockholm, Sweden, produced the vaccine and placebo agents for the study. ACO Ltd, Stockholm, Sweden, prepared antacid tablets for administration with the vaccines and placebo. This work was supported by funds from the United States Agency for International Development, the Government of Japan, the Swedish Agency for Research Cooperation with Developing Countries, and the World Health Organisation.",
year = "1986",
month = jul,
day = "19",
doi = "10.1016/S0140-6736(86)91944-6",
language = "English (US)",
volume = "328",
pages = "124--127",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "8499",
}