FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH

John D. Clemens; Jeffrey R. Harris; M. R. Khan; Bradford A. Kay; Md Yunus; Ann Mari Svennerholm; David A. Sack; J. Chakraborty; Bonita F. Stanton; M. U. Khan; William Atkinson; Jan Holmgren

doi:10.1016/S0140-6736(86)91944-6

FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH

John D. Clemens, Jeffrey R. Harris, M. R. Khan, Bradford A. Kay, Md Yunus, Ann Mari Svennerholm, David A. Sack, J. Chakraborty, Bonita F. Stanton, M. U. Khan, William Atkinson, Jan Holmgren

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

The protective efficacy of oral B subunit killed whole-cell (BS-WC) and killed whole-cell (WC) cholera vaccines was assessed in 63 498 Bangladeshi children aged 2-15 years and women aged over 15 years. Each received three doses of BS-WC, WC, or placebo in a randomised, double-blinded fashion. Surveillance for cases seeking medical care up to six months after the third dose revealed 26 cases of confirmed cholera in the placebo group, 4 cases in the BS-WC group (protective efficacy 85%; p<0·0001), and 11 cases in the WC group (protective efficacy 58%; p<0·01). For each vaccine protective efficacy was consistent in different age-groups (2-10 years versus >10 years) and for different severities of cholera.

Original language	English (US)
Pages (from-to)	124-127
Number of pages	4
Journal	The Lancet
Volume	328
Issue number	8499
DOIs	https://doi.org/10.1016/S0140-6736(86)91944-6
State	Published - Jul 19 1986

ASJC Scopus subject areas

Medicine(all)

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FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH. / Clemens, John D.; Harris, Jeffrey R.; Khan, M. R.; Kay, Bradford A.; Yunus, Md; Svennerholm, Ann Mari; Sack, David A.; Chakraborty, J.; Stanton, Bonita F.; Khan, M. U.; Atkinson, William; Holmgren, Jan.

In: The Lancet, Vol. 328, No. 8499, 19.07.1986, p. 124-127.

Research output: Contribution to journal › Article › peer-review

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abstract = "The protective efficacy of oral B subunit killed whole-cell (BS-WC) and killed whole-cell (WC) cholera vaccines was assessed in 63 498 Bangladeshi children aged 2-15 years and women aged over 15 years. Each received three doses of BS-WC, WC, or placebo in a randomised, double-blinded fashion. Surveillance for cases seeking medical care up to six months after the third dose revealed 26 cases of confirmed cholera in the placebo group, 4 cases in the BS-WC group (protective efficacy 85%; p<0·0001), and 11 cases in the WC group (protective efficacy 58%; p<0·01). For each vaccine protective efficacy was consistent in different age-groups (2-10 years versus >10 years) and for different severities of cholera.",

author = "Clemens, {John D.} and Harris, {Jeffrey R.} and Khan, {M. R.} and Kay, {Bradford A.} and Md Yunus and Svennerholm, {Ann Mari} and Sack, {David A.} and J. Chakraborty and Stanton, {Bonita F.} and Khan, {M. U.} and William Atkinson and Jan Holmgren",

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AU - Clemens, John D.

AU - Harris, Jeffrey R.

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AU - Yunus, Md

AU - Svennerholm, Ann Mari

AU - Sack, David A.

AU - Chakraborty, J.

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AU - Khan, M. U.

AU - Atkinson, William

AU - Holmgren, Jan

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AB - The protective efficacy of oral B subunit killed whole-cell (BS-WC) and killed whole-cell (WC) cholera vaccines was assessed in 63 498 Bangladeshi children aged 2-15 years and women aged over 15 years. Each received three doses of BS-WC, WC, or placebo in a randomised, double-blinded fashion. Surveillance for cases seeking medical care up to six months after the third dose revealed 26 cases of confirmed cholera in the placebo group, 4 cases in the BS-WC group (protective efficacy 85%; p<0·0001), and 11 cases in the WC group (protective efficacy 58%; p<0·01). For each vaccine protective efficacy was consistent in different age-groups (2-10 years versus >10 years) and for different severities of cholera.

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