FIELD TRIAL OF ORAL CHOLERA VACCINES IN BANGLADESH

John D. Clemens, Jeffrey R. Harris, M. R. Khan, Bradford A. Kay, Md Yunus, Ann Mari Svennerholm, David A. Sack, J. Chakraborty, Bonita F. Stanton, M. U. Khan, William Atkinson, Jan Holmgren

Research output: Contribution to journalArticlepeer-review

Abstract

The protective efficacy of oral B subunit killed whole-cell (BS-WC) and killed whole-cell (WC) cholera vaccines was assessed in 63 498 Bangladeshi children aged 2-15 years and women aged over 15 years. Each received three doses of BS-WC, WC, or placebo in a randomised, double-blinded fashion. Surveillance for cases seeking medical care up to six months after the third dose revealed 26 cases of confirmed cholera in the placebo group, 4 cases in the BS-WC group (protective efficacy 85%; p<0·0001), and 11 cases in the WC group (protective efficacy 58%; p<0·01). For each vaccine protective efficacy was consistent in different age-groups (2-10 years versus >10 years) and for different severities of cholera.

Original languageEnglish (US)
Pages (from-to)124-127
Number of pages4
JournalThe Lancet
Volume328
Issue number8499
DOIs
StatePublished - Jul 19 1986

ASJC Scopus subject areas

  • Medicine(all)

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