Field trial of inactivated oral cholera vaccines in Bangladesh: Results from 5 years of follow-up

F. P.L. Van Loon, J. D. Clemens, J. Chakraborty, M. R. Rao, B. A. Kay, D. A. Sack, Md Yunus, Md Ali, A. M. Svennerholm, J. Holmgren

Research output: Contribution to journalArticle

Abstract

To determine the protective efficacy (PE) of three doses of oral B subunit-killed whole cell (BS-WC) or killed whole cell-only (WC) vaccines against cholera, a clinical trial was conducted among 62285 children over 2 years and adult women in rural Bangladesh. During 5 years of follow-up, there were 144 cases of cholera in the BS-WC group (PE = 49%; P < 0.001), 150 in the WC group (PE = 47%; P < 0.001), and 283 in the K12 group. Protection by each vaccine was evident only during the first three years of follow-up; long-term protection of young children was observed only against classical but not El Tor cholera; 3-year protection against both cholera biotypes occurred among older persons, but at a higher level against classical cholera.

Original languageEnglish (US)
Pages (from-to)162-166
Number of pages5
JournalVaccine
Volume14
Issue number2
DOIs
StatePublished - Feb 1996

Keywords

  • Bangladesh
  • Cholera
  • Oral vaccination

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Van Loon, F. P. L., Clemens, J. D., Chakraborty, J., Rao, M. R., Kay, B. A., Sack, D. A., Yunus, M., Ali, M., Svennerholm, A. M., & Holmgren, J. (1996). Field trial of inactivated oral cholera vaccines in Bangladesh: Results from 5 years of follow-up. Vaccine, 14(2), 162-166. https://doi.org/10.1016/0264-410X(95)00122-H