Field trial of inactivated oral cholera vaccines in Bangladesh: Results from 5 years of follow-up

F. P.L. Van Loon; J. D. Clemens; J. Chakraborty; M. R. Rao; B. A. Kay; D. A. Sack; Md Yunus; Md Ali; A. M. Svennerholm; J. Holmgren

doi:10.1016/0264-410X(95)00122-H

Field trial of inactivated oral cholera vaccines in Bangladesh: Results from 5 years of follow-up

F. P.L. Van Loon, J. D. Clemens, J. Chakraborty, M. R. Rao, B. A. Kay, D. A. Sack, Md Yunus, Md Ali, A. M. Svennerholm, J. Holmgren

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

To determine the protective efficacy (PE) of three doses of oral B subunit-killed whole cell (BS-WC) or killed whole cell-only (WC) vaccines against cholera, a clinical trial was conducted among 62285 children over 2 years and adult women in rural Bangladesh. During 5 years of follow-up, there were 144 cases of cholera in the BS-WC group (PE = 49%; P < 0.001), 150 in the WC group (PE = 47%; P < 0.001), and 283 in the K12 group. Protection by each vaccine was evident only during the first three years of follow-up; long-term protection of young children was observed only against classical but not El Tor cholera; 3-year protection against both cholera biotypes occurred among older persons, but at a higher level against classical cholera.

Original language	English (US)
Pages (from-to)	162-166
Number of pages	5
Journal	Vaccine
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/0264-410X(95)00122-H
State	Published - Feb 1996

Keywords

Bangladesh
Cholera
Oral vaccination

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/0264-410X(95)00122-H

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title = "Field trial of inactivated oral cholera vaccines in Bangladesh: Results from 5 years of follow-up",

abstract = "To determine the protective efficacy (PE) of three doses of oral B subunit-killed whole cell (BS-WC) or killed whole cell-only (WC) vaccines against cholera, a clinical trial was conducted among 62285 children over 2 years and adult women in rural Bangladesh. During 5 years of follow-up, there were 144 cases of cholera in the BS-WC group (PE = 49%; P < 0.001), 150 in the WC group (PE = 47%; P < 0.001), and 283 in the K12 group. Protection by each vaccine was evident only during the first three years of follow-up; long-term protection of young children was observed only against classical but not El Tor cholera; 3-year protection against both cholera biotypes occurred among older persons, but at a higher level against classical cholera.",

keywords = "Bangladesh, Cholera, Oral vaccination",

author = "{Van Loon}, {F. P.L.} and Clemens, {J. D.} and J. Chakraborty and Rao, {M. R.} and Kay, {B. A.} and Sack, {D. A.} and Md Yunus and Md Ali and Svennerholm, {A. M.} and J. Holmgren",

year = "1996",

month = feb,

doi = "10.1016/0264-410X(95)00122-H",

language = "English (US)",

volume = "14",

pages = "162--166",

journal = "Vaccine",

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T1 - Field trial of inactivated oral cholera vaccines in Bangladesh

T2 - Results from 5 years of follow-up

AU - Van Loon, F. P.L.

AU - Clemens, J. D.

AU - Chakraborty, J.

AU - Rao, M. R.

AU - Kay, B. A.

AU - Sack, D. A.

AU - Yunus, Md

AU - Ali, Md

AU - Svennerholm, A. M.

AU - Holmgren, J.

PY - 1996/2

Y1 - 1996/2

N2 - To determine the protective efficacy (PE) of three doses of oral B subunit-killed whole cell (BS-WC) or killed whole cell-only (WC) vaccines against cholera, a clinical trial was conducted among 62285 children over 2 years and adult women in rural Bangladesh. During 5 years of follow-up, there were 144 cases of cholera in the BS-WC group (PE = 49%; P < 0.001), 150 in the WC group (PE = 47%; P < 0.001), and 283 in the K12 group. Protection by each vaccine was evident only during the first three years of follow-up; long-term protection of young children was observed only against classical but not El Tor cholera; 3-year protection against both cholera biotypes occurred among older persons, but at a higher level against classical cholera.

AB - To determine the protective efficacy (PE) of three doses of oral B subunit-killed whole cell (BS-WC) or killed whole cell-only (WC) vaccines against cholera, a clinical trial was conducted among 62285 children over 2 years and adult women in rural Bangladesh. During 5 years of follow-up, there were 144 cases of cholera in the BS-WC group (PE = 49%; P < 0.001), 150 in the WC group (PE = 47%; P < 0.001), and 283 in the K12 group. Protection by each vaccine was evident only during the first three years of follow-up; long-term protection of young children was observed only against classical but not El Tor cholera; 3-year protection against both cholera biotypes occurred among older persons, but at a higher level against classical cholera.

KW - Bangladesh

KW - Cholera

KW - Oral vaccination

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AN - SCOPUS:18744426232

SN - 0264-410X

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EP - 166

JO - Vaccine

JF - Vaccine

IS - 2

ER -

Field trial of inactivated oral cholera vaccines in Bangladesh: Results from 5 years of follow-up

Abstract

Keywords

ASJC Scopus subject areas

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