Field evaluation of five rapid diagnostic tests for screening of HIV-1 infections in rural Rakai, Uganda

S. C. Kagulire, P. Opendi, Paul Stamper, J. L. Nakavuma, L. A. Mills, F. Makumbi, Ronald H Gray, J. P. Shott, D. Serwadda, Steven James Reynolds

Research output: Contribution to journalArticle

Abstract

The performance characteristics of HIV rapid diagnostic tests (RDTs) vary by test and by population. We assessed five commercial RDTs in Uganda where all but one RDT (Determine; Abbott Laboratories, Germany) performed close to manufacturer's expectations. Determine had low specificity (85.2%, positive predictive value 67.3%) due to false-positive results with weakpositive bands. Properly trained staff, good quality control programmes and validation of RDTs with laboratories having confirmatory testing capacity may be warranted to assure accuracy in each setting.

Original languageEnglish (US)
Pages (from-to)308-309
Number of pages2
JournalInternational Journal of STD and AIDS
Volume22
Issue number6
DOIs
StatePublished - Jun 2011

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Uganda
Routine Diagnostic Tests
HIV Infections
HIV-1
Quality Control
Germany
HIV
Population

Keywords

  • HIV
  • Point of care tests
  • Rapid diagnostic testing
  • Resource-poor settings
  • Uganda

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Field evaluation of five rapid diagnostic tests for screening of HIV-1 infections in rural Rakai, Uganda. / Kagulire, S. C.; Opendi, P.; Stamper, Paul; Nakavuma, J. L.; Mills, L. A.; Makumbi, F.; Gray, Ronald H; Shott, J. P.; Serwadda, D.; Reynolds, Steven James.

In: International Journal of STD and AIDS, Vol. 22, No. 6, 06.2011, p. 308-309.

Research output: Contribution to journalArticle

Kagulire, S. C. ; Opendi, P. ; Stamper, Paul ; Nakavuma, J. L. ; Mills, L. A. ; Makumbi, F. ; Gray, Ronald H ; Shott, J. P. ; Serwadda, D. ; Reynolds, Steven James. / Field evaluation of five rapid diagnostic tests for screening of HIV-1 infections in rural Rakai, Uganda. In: International Journal of STD and AIDS. 2011 ; Vol. 22, No. 6. pp. 308-309.
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