Field evaluation of five rapid diagnostic tests for screening of HIV-1 infections in rural Rakai, Uganda

S. C. Kagulire, P. Opendi, P. D. Stamper, J. L. Nakavuma, L. A. Mills, F. Makumbi, R. H. Gray, J. P. Shott, D. Serwadda, S. J. Reynolds

Research output: Contribution to journalArticle

Abstract

The performance characteristics of HIV rapid diagnostic tests (RDTs) vary by test and by population. We assessed five commercial RDTs in Uganda where all but one RDT (Determine; Abbott Laboratories, Germany) performed close to manufacturer's expectations. Determine had low specificity (85.2%, positive predictive value 67.3%) due to false-positive results with weakpositive bands. Properly trained staff, good quality control programmes and validation of RDTs with laboratories having confirmatory testing capacity may be warranted to assure accuracy in each setting.

Original languageEnglish (US)
Pages (from-to)308-309
Number of pages2
JournalInternational Journal of STD and AIDS
Volume22
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • HIV
  • Point of care tests
  • Rapid diagnostic testing
  • Resource-poor settings
  • Uganda

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

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