Field cancerization in mammary tissues

Marco Bisoffi, Christopher M. Heaphy, Jeffrey K. Griffith

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In this chapter we review published evidence for field cancerization within human mammary tissues. First, breast tissue development and morphology is revisited with a focus on the different cell types that can be affected by or contribute to field cancerization. Different definitions and possible concepts and cellular mechanisms of breast field cancerization are also presented. This is followed by a review of published molecular data including genetic, epigenetic, and expressional that is in support of mammary field cancerization. We then discuss the clinical importance of field cancerization in breast tissues as a source for biomarkers with diagnostic and prognostic potential, and its relationship to surgical margins and disease recurrence. We conclude with a future outlook of further research in breast field cancerization addressing experimental methods and the development of possible models to increase knowledge of this important field of research.

Original languageEnglish (US)
Title of host publicationField Cancerization
Subtitle of host publicationBasic Science and Clinical Applications
PublisherNova Science Publishers, Inc.
Pages145-186
Number of pages42
ISBN (Print)9781617610066
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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