Fibromatoses of the extremities: Clinicopathologic study of 36 cases

Anupamjit K. Mehrotra, Salwa Sheikh, Alan D. Aaron, Elizabeth Montgomery, John R. Goldblum

Research output: Contribution to journalArticlepeer-review


Background and Objectives: Fibromatoses of the extremities are rare and often recalcitrant to treatment. We evaluated the clinical and pathologic features of a group of extremity fibromatoses treated by surgical excision with or without adjuvant therapy to determine if any clinical or pathologic parameters were predictive of clinical outcome. Methods: Thirty-six extremity fibromatoses were evaluated. A number of clinical and histologic features were correlated with risk of local recurrence. Results: The cohort included 19 females and 17 males with ages ranging from 11-72 years (mean: 35 years), with 12 tumors of the upper and 24 tumors of the lower extremity. Tumors ranged in size from 1.5-15.5 cm (mean: 7.5 cm). Histologically, 26 were infiltrative, 3 had pushing borders and 7 had both. Mitotic counts ranged from 0-5/50 high-power fields (mean: 0.74). Surgical margins were positive in 22 cases. Seventeen patients were treated with postoperative adjuvant therapy including radiation therapy and tamoxifen. Follow-up information was available in 34 cases (from 1-202 months; mean: 83 months). Nineteen patients (56%) had recurrences, including 11 with multiple recurrences (range to first recurrence: 5-61 months; mean 23 months). Seventy-one percent of patients with a positive surgical margin and clinical follow-up had a local recurrence, compared to 31% with a negative surgical margin (P < 0.05). None of the other clinical or histologic parameters correlated with the risk for local recurrence. Conclusions: Local control in fibromatoses of the extremities remains problematic. Aside from positive surgical margins, none of the other clinical or histologic parameters evaluated in this study were useful in predicting the risk of local recurrence. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)291-296
Number of pages6
JournalJournal of Surgical Oncology
Issue number4
StatePublished - Sep 11 2000
Externally publishedYes


  • Extremity
  • Fibromatosis
  • Surgical margins

ASJC Scopus subject areas

  • Surgery
  • Oncology


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