Fibrolamellar hepatocellular carcinoma

A. C. Friedman, J. E. Lichtenstein, Z. Goodman, E. K. Fishman, Stanley S Siegelman, A. H. Dachman

Research output: Contribution to journalArticlepeer-review


Fibrolamellar hepatocellular carcinoma (HCC) has recently been separated as a distinct clinicopathologic entity with a better prognosis than the usual HCC associated with cirrhosis. The mean age of our 17 patients was 20 years. Alpha fetoprotein levels were normal, and none of the risk factors for HCC was present. Distinctive histologic features included deeply eosinophilic polygonal hepatocytes and abundant fibrous stroma. Calcification was present on plain films of five of 13 cases. Sonography usually showed a homogeneous, echogenic mass. Computed tomography (CT) demonstrated small, central calcification in four of ten cases. A central echodensity, hypodense on CT scans, was seen in two cases and corresponded to a central scar. By combining clinical and laboratory data with radiological tests, a correct diagnosis can often be suggested before biopsy is performed.

Original languageEnglish (US)
Pages (from-to)583-587
Number of pages5
Issue number3
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Fibrolamellar hepatocellular carcinoma'. Together they form a unique fingerprint.

Cite this