Fibroblast implantation enhances wound healing as indicated by breaking strength determinations

W. W.O. Krueger, H. Goepfert, M. Romsdahl, J. Herson, R. H. Withers, R. H. Jesse

Research output: Contribution to journalArticlepeer-review

Abstract

Irradiation of normal tissues at the dose/time factor employed in the treatment of solid tumors impairs the subsequent healing of surgical wounds made in those tissues. Irreversible radiation damage to regional fibroblasts is one cause of impaired healing. This study was conducted to determine whether syngeneic guinea pig fibroblasts, harvested from tissue culture when injected into irradiated guinea pig skin at the time of wound closure, could improve wound healing. Breaking strength determinations indicate that irradiated wounds demonstrate enhanced wound healing if implanted with fibroblasts.

Original languageEnglish (US)
Pages (from-to)804-811
Number of pages8
JournalOtolaryngology - Head and Neck Surgery
Volume86
Issue number5
StatePublished - Dec 1 1978
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Fibroblast implantation enhances wound healing as indicated by breaking strength determinations'. Together they form a unique fingerprint.

Cite this