Fibroblast growth factor (FGF) homologous factors: New members of the FGF family implicated in nervous system development

Philip M. Smallwood, Ignacio Munoz-Sanjuan, Patrick Tong, Jennifer P. Macke, Stewart H Hendry, Debra J. Gilbert, Neal G. Copeland, Nancy A. Jenkins, Jeremy Nathans

Research output: Contribution to journalArticle

Abstract

Four new members of the fibroblast growth factor (FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a combination of random cDNA sequencing, data base searches, and degenerate PCR. Pairwise comparisons between the four FHFs show between 58% and 71% amino acid sequence identity, but each FHF shows less than 30% identity when compared with other FGFs. Like FGF-1 (acidic FGF) and FGF-2 {basic FGF), the FHFs lack a classical signal sequence and contain clusters of basic residues that can act as nuclear localization signals. In transiently transfected 293 cells FHF-1 accumulates in the nucleus and is not secreted. Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function.

Original languageEnglish (US)
Pages (from-to)9850-9857
Number of pages8
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number18
DOIs
StatePublished - Sep 3 1996

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Fibroblast Growth Factors
Nervous System
Fibroblast Growth Factor 1
Fibroblast Growth Factor 2
Nuclear Localization Signals
Protein Sorting Signals
Amino Acid Sequence
Complementary DNA
Databases
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Genetics
  • General

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Fibroblast growth factor (FGF) homologous factors : New members of the FGF family implicated in nervous system development. / Smallwood, Philip M.; Munoz-Sanjuan, Ignacio; Tong, Patrick; Macke, Jennifer P.; Hendry, Stewart H; Gilbert, Debra J.; Copeland, Neal G.; Jenkins, Nancy A.; Nathans, Jeremy.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, No. 18, 03.09.1996, p. 9850-9857.

Research output: Contribution to journalArticle

Smallwood, Philip M. ; Munoz-Sanjuan, Ignacio ; Tong, Patrick ; Macke, Jennifer P. ; Hendry, Stewart H ; Gilbert, Debra J. ; Copeland, Neal G. ; Jenkins, Nancy A. ; Nathans, Jeremy. / Fibroblast growth factor (FGF) homologous factors : New members of the FGF family implicated in nervous system development. In: Proceedings of the National Academy of Sciences of the United States of America. 1996 ; Vol. 93, No. 18. pp. 9850-9857.
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