TY - JOUR
T1 - Fibroblast growth factor (FGF) homologous factors
T2 - New members of the FGF family implicated in nervous system development
AU - Smallwood, Philip M.
AU - Munoz-Sanjuan, Ignacio
AU - Tong, Patrick
AU - Macke, Jennifer P.
AU - Hendry, Stewart H.C.
AU - Gilbert, Debra J.
AU - Copeland, Neal G.
AU - Jenkins, Nancy A.
AU - Nathans, Jeremy
PY - 1996/9/3
Y1 - 1996/9/3
N2 - Four new members of the fibroblast growth factor (FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a combination of random cDNA sequencing, data base searches, and degenerate PCR. Pairwise comparisons between the four FHFs show between 58% and 71% amino acid sequence identity, but each FHF shows less than 30% identity when compared with other FGFs. Like FGF-1 (acidic FGF) and FGF-2 {basic FGF), the FHFs lack a classical signal sequence and contain clusters of basic residues that can act as nuclear localization signals. In transiently transfected 293 cells FHF-1 accumulates in the nucleus and is not secreted. Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function.
AB - Four new members of the fibroblast growth factor (FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a combination of random cDNA sequencing, data base searches, and degenerate PCR. Pairwise comparisons between the four FHFs show between 58% and 71% amino acid sequence identity, but each FHF shows less than 30% identity when compared with other FGFs. Like FGF-1 (acidic FGF) and FGF-2 {basic FGF), the FHFs lack a classical signal sequence and contain clusters of basic residues that can act as nuclear localization signals. In transiently transfected 293 cells FHF-1 accumulates in the nucleus and is not secreted. Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function.
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U2 - 10.1073/pnas.93.18.9850
DO - 10.1073/pnas.93.18.9850
M3 - Article
C2 - 8790420
AN - SCOPUS:0029820043
SN - 0027-8424
VL - 93
SP - 9850
EP - 9857
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 18
ER -