Fibroblast growth factor 9 enhances chondrocyte proliferation and phenotype expression in monolayer and microcarrier cultures

R. T. Degnan, S. De, A. V. Polotsky, D. S. Hungerford, C. G. Frondoza

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effect of FGF-9 on the proliferative capacity and production of cartilage-specific extracellular matrix (ECM) components between a microcarrier culture system and a monolayer system was investigated. The study also provided evidence to illustrate that microcarrier cultures enhance chondrocyte growth and proliferation to a greater degree than monolayer cultures. It was observed that the collagen microcarrier beads facilitate amplification of chondrocyte numbers and continued extracellular matrix assembly. It was suggested that the superior environment offered by the microcarrier system may prove useful in cartilage repair.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

ASJC Scopus subject areas

  • Engineering(all)

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