Fibroblast Growth Factor 23–Mediated Bone Disease

Anda R. Gonciulea, Suzanne M Jan De Beur

Research output: Contribution to journalReview article

Abstract

Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders associated with FGF23 excess or deficiency.

Original languageEnglish (US)
Pages (from-to)19-39
Number of pages21
JournalEndocrinology and Metabolism Clinics of North America
Volume46
Issue number1
DOIs
StatePublished - Mar 1 2017

Fingerprint

Fibroblast Growth Factors
Bone Diseases
Vitamin D
Phosphates
fibroblast growth factor 23

Keywords

  • FGF23
  • Hyperphosphatemia
  • Hypophosphatemia
  • Osteomalacia
  • Rickets
  • α-Klotho

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Fibroblast Growth Factor 23–Mediated Bone Disease. / Gonciulea, Anda R.; Jan De Beur, Suzanne M.

In: Endocrinology and Metabolism Clinics of North America, Vol. 46, No. 1, 01.03.2017, p. 19-39.

Research output: Contribution to journalReview article

@article{d77165b843844ec9832755cda6a2313b,
title = "Fibroblast Growth Factor 23–Mediated Bone Disease",
abstract = "Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders associated with FGF23 excess or deficiency.",
keywords = "FGF23, Hyperphosphatemia, Hypophosphatemia, Osteomalacia, Rickets, α-Klotho",
author = "Gonciulea, {Anda R.} and {Jan De Beur}, {Suzanne M}",
year = "2017",
month = "3",
day = "1",
doi = "10.1016/j.ecl.2016.09.013",
language = "English (US)",
volume = "46",
pages = "19--39",
journal = "Endocrinology and Metabolism Clinics of North America",
issn = "0889-8529",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Fibroblast Growth Factor 23–Mediated Bone Disease

AU - Gonciulea, Anda R.

AU - Jan De Beur, Suzanne M

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders associated with FGF23 excess or deficiency.

AB - Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders associated with FGF23 excess or deficiency.

KW - FGF23

KW - Hyperphosphatemia

KW - Hypophosphatemia

KW - Osteomalacia

KW - Rickets

KW - α-Klotho

UR - http://www.scopus.com/inward/record.url?scp=85007560468&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85007560468&partnerID=8YFLogxK

U2 - 10.1016/j.ecl.2016.09.013

DO - 10.1016/j.ecl.2016.09.013

M3 - Review article

C2 - 28131132

AN - SCOPUS:85007560468

VL - 46

SP - 19

EP - 39

JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

SN - 0889-8529

IS - 1

ER -