Fibroblast Growth Factor 23–Mediated Bone Disease

Anda R. Gonciulea; Suzanne M Jan De Beur

doi:10.1016/j.ecl.2016.09.013

Fibroblast Growth Factor 23–Mediated Bone Disease

Anda R. Gonciulea, Suzanne M Jan De Beur

School of Medicine

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders associated with FGF23 excess or deficiency.

Original language	English (US)
Pages (from-to)	19-39
Number of pages	21
Journal	Endocrinology and Metabolism Clinics of North America
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/j.ecl.2016.09.013
State	Published - Mar 1 2017

Keywords

FGF23
Hyperphosphatemia
Hypophosphatemia
Osteomalacia
Rickets
α-Klotho

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.ecl.2016.09.013

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title = "Fibroblast Growth Factor 23–Mediated Bone Disease",

abstract = "Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders associated with FGF23 excess or deficiency.",

keywords = "FGF23, Hyperphosphatemia, Hypophosphatemia, Osteomalacia, Rickets, α-Klotho",

author = "Gonciulea, {Anda R.} and {Jan De Beur}, {Suzanne M}",

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AU - Jan De Beur, Suzanne M

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N2 - Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders associated with FGF23 excess or deficiency.

AB - Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders associated with FGF23 excess or deficiency.

KW - FGF23

KW - Hyperphosphatemia

KW - Hypophosphatemia

KW - Osteomalacia

KW - Rickets

KW - α-Klotho

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DO - 10.1016/j.ecl.2016.09.013

M3 - Review article

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AN - SCOPUS:85007560468

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IS - 1

ER -

Fibroblast Growth Factor 23–Mediated Bone Disease

Abstract

Keywords

ASJC Scopus subject areas

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