Fibroblast Growth Factor 23–Mediated Bone Disease

Anda R. Gonciulea, Suzanne M Jan De Beur

Research output: Contribution to journalReview article


Fibroblast growth factor 23 (FGF23) is an important regulator of phosphate and vitamin D metabolism and its excessive or insufficient production leads to a wide variety of skeletal disorders. This article reviews the FGF23-α-Klotho signaling pathway, highlighting the latest developments in FGF23 regulation and action, and describes the disorders associated with FGF23 excess or deficiency.

Original languageEnglish (US)
Pages (from-to)19-39
Number of pages21
JournalEndocrinology and Metabolism Clinics of North America
Issue number1
Publication statusPublished - Mar 1 2017



  • FGF23
  • Hyperphosphatemia
  • Hypophosphatemia
  • Osteomalacia
  • Rickets
  • α-Klotho

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this