Fibro-neuronal guidance on common, 3D-printed textured substrates

Agata Blasiak, Thomas H.M. Guerin, Daniel B.L. Teh, In Hong Yang, Amitabha Lahiri, Nitish V. Thakor

Research output: Contribution to journalArticlepeer-review

Abstract

Ability to direct neuronal growth not only carries great potential for treating neural conditions-for example, bridging traumatically shattered connections-but would also be an exquisite tool for bionic applications that require a physical interface between neurons and electronics. A testing platform is needed to better understand axonal guidance in the context of a specific in vivo application. Versatility of 3D printing technology allows tailoring to researcher needs, both in vitro and in vivo. In this paper, we establish a fibro-neuronal co-culture inspired by our neural interface research and demonstrate axon alignment on a textured substrate fabricated with a common, versatile 3D-printing set-up.

Original languageEnglish (US)
Article number8667846
Pages (from-to)226-229
Number of pages4
JournalIEEE Transactions on Nanobioscience
Volume18
Issue number2
DOIs
StatePublished - Apr 2019
Externally publishedYes

Keywords

  • 3D printing
  • VeroClear
  • axon guidance
  • biocompatible
  • co-culture
  • fibro-neuronal
  • neural interface
  • texturization

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmaceutical Science
  • Computer Science Applications
  • Electrical and Electronic Engineering

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