Fibro-Neuronal Guidance on Common, 3D-Printed Textured Substrates

Agata Blasiak, Thomas H.M. Guerin, Daniel B.L. Teh, In Hong Yang, Amit Lahiri, Nitish V Thakor

Research output: Contribution to journalArticle

Abstract

Ability to direct neuronal growth not only carries great potential for treating neural conditions -e.g. bridging traumatically shattered connections - but would also be an exquisite tool for bionic applications that require physical interface between neurons and electronics. A testing platform is needed to better understand axonal guidance in the context of a specific in-vivo application. Versatility of 3D printing technology allows tailoring to researcher needs, both in-vitro and in-vivo. In this study we establish a fibro-neuronal co-culture inspired by our neural interface research, and demonstrate axon alignment on a texturized substrate fabricated with a common, versatile 3D-printing set-up.

Original languageEnglish (US)
JournalIEEE Transactions on Nanobioscience
DOIs
StateAccepted/In press - Jan 1 2019
Externally publishedYes

Keywords

  • Axons
  • Fibroblasts
  • Histograms
  • Nanobioscience
  • Printing
  • Substrates

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Pharmaceutical Science
  • Computer Science Applications
  • Electrical and Electronic Engineering

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