Fibrinolytic therapy for upper-extremity arterial occlusions

David M. Widlus, Anthony C. Venbrux, James F. Benenati, Sally E Mitchell, Alma Lynch-Nyhan, Francis P. Cassidy, Floyd A. Osterman

Research output: Contribution to journalArticle

Abstract

Acute upper-extremity arterial occlusion may be due to embolic phenomena or de novo thrombosis. If the occlusion is left untreated, claudication or ischemia necessitating amputation can occur. Operative Fogarty-balloon embolectomy has been the treatment of choice for this entity. In a 6-year period the authors used f ibrinolysis on nine occasions in eight patients to treat acute upper-extremity arterial occlusions. Concomitant balloon angioplasty was helpful in four cases. Success, defined as a normal hand with at least one artery that was continuously patent to the wrist, was achieved in all patients. A single significant groin hematoma was seen. Neither stroke nor death occurred in any case, and no amputations were necessary. Local transcatheter intraarterial administration of urokinase can be considered a first-line treatment for brachial artery embolus and other causes of acute upper-extremity arterial occlusion.

Original languageEnglish (US)
Pages (from-to)393-399
Number of pages7
JournalRadiology
Volume175
Issue number2
StatePublished - May 1990

Fingerprint

Thrombolytic Therapy
Upper Extremity
Amputation
Balloon Embolectomy
Balloon Angioplasty
Brachial Artery
Groin
Urokinase-Type Plasminogen Activator
Embolism
Wrist
Hematoma
Thrombosis
Ischemia
Hand
Arteries
Stroke
Therapeutics

Keywords

  • Arteries, extremities, 91.1274
  • Arteries, stenosis or obstruction, 91.77
  • Extremities, thrombosis, 91.77
  • Fibrinolysis, 91.1274
  • Streptokinase, 91.1274
  • Thrombosis, arterial, 91.77
  • Urokinase, 91.1274

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Widlus, D. M., Venbrux, A. C., Benenati, J. F., Mitchell, S. E., Lynch-Nyhan, A., Cassidy, F. P., & Osterman, F. A. (1990). Fibrinolytic therapy for upper-extremity arterial occlusions. Radiology, 175(2), 393-399.

Fibrinolytic therapy for upper-extremity arterial occlusions. / Widlus, David M.; Venbrux, Anthony C.; Benenati, James F.; Mitchell, Sally E; Lynch-Nyhan, Alma; Cassidy, Francis P.; Osterman, Floyd A.

In: Radiology, Vol. 175, No. 2, 05.1990, p. 393-399.

Research output: Contribution to journalArticle

Widlus, DM, Venbrux, AC, Benenati, JF, Mitchell, SE, Lynch-Nyhan, A, Cassidy, FP & Osterman, FA 1990, 'Fibrinolytic therapy for upper-extremity arterial occlusions', Radiology, vol. 175, no. 2, pp. 393-399.
Widlus DM, Venbrux AC, Benenati JF, Mitchell SE, Lynch-Nyhan A, Cassidy FP et al. Fibrinolytic therapy for upper-extremity arterial occlusions. Radiology. 1990 May;175(2):393-399.
Widlus, David M. ; Venbrux, Anthony C. ; Benenati, James F. ; Mitchell, Sally E ; Lynch-Nyhan, Alma ; Cassidy, Francis P. ; Osterman, Floyd A. / Fibrinolytic therapy for upper-extremity arterial occlusions. In: Radiology. 1990 ; Vol. 175, No. 2. pp. 393-399.
@article{f1421e74eb8141a793802775a323d297,
title = "Fibrinolytic therapy for upper-extremity arterial occlusions",
abstract = "Acute upper-extremity arterial occlusion may be due to embolic phenomena or de novo thrombosis. If the occlusion is left untreated, claudication or ischemia necessitating amputation can occur. Operative Fogarty-balloon embolectomy has been the treatment of choice for this entity. In a 6-year period the authors used f ibrinolysis on nine occasions in eight patients to treat acute upper-extremity arterial occlusions. Concomitant balloon angioplasty was helpful in four cases. Success, defined as a normal hand with at least one artery that was continuously patent to the wrist, was achieved in all patients. A single significant groin hematoma was seen. Neither stroke nor death occurred in any case, and no amputations were necessary. Local transcatheter intraarterial administration of urokinase can be considered a first-line treatment for brachial artery embolus and other causes of acute upper-extremity arterial occlusion.",
keywords = "Arteries, extremities, 91.1274, Arteries, stenosis or obstruction, 91.77, Extremities, thrombosis, 91.77, Fibrinolysis, 91.1274, Streptokinase, 91.1274, Thrombosis, arterial, 91.77, Urokinase, 91.1274",
author = "Widlus, {David M.} and Venbrux, {Anthony C.} and Benenati, {James F.} and Mitchell, {Sally E} and Alma Lynch-Nyhan and Cassidy, {Francis P.} and Osterman, {Floyd A.}",
year = "1990",
month = "5",
language = "English (US)",
volume = "175",
pages = "393--399",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "2",

}

TY - JOUR

T1 - Fibrinolytic therapy for upper-extremity arterial occlusions

AU - Widlus, David M.

AU - Venbrux, Anthony C.

AU - Benenati, James F.

AU - Mitchell, Sally E

AU - Lynch-Nyhan, Alma

AU - Cassidy, Francis P.

AU - Osterman, Floyd A.

PY - 1990/5

Y1 - 1990/5

N2 - Acute upper-extremity arterial occlusion may be due to embolic phenomena or de novo thrombosis. If the occlusion is left untreated, claudication or ischemia necessitating amputation can occur. Operative Fogarty-balloon embolectomy has been the treatment of choice for this entity. In a 6-year period the authors used f ibrinolysis on nine occasions in eight patients to treat acute upper-extremity arterial occlusions. Concomitant balloon angioplasty was helpful in four cases. Success, defined as a normal hand with at least one artery that was continuously patent to the wrist, was achieved in all patients. A single significant groin hematoma was seen. Neither stroke nor death occurred in any case, and no amputations were necessary. Local transcatheter intraarterial administration of urokinase can be considered a first-line treatment for brachial artery embolus and other causes of acute upper-extremity arterial occlusion.

AB - Acute upper-extremity arterial occlusion may be due to embolic phenomena or de novo thrombosis. If the occlusion is left untreated, claudication or ischemia necessitating amputation can occur. Operative Fogarty-balloon embolectomy has been the treatment of choice for this entity. In a 6-year period the authors used f ibrinolysis on nine occasions in eight patients to treat acute upper-extremity arterial occlusions. Concomitant balloon angioplasty was helpful in four cases. Success, defined as a normal hand with at least one artery that was continuously patent to the wrist, was achieved in all patients. A single significant groin hematoma was seen. Neither stroke nor death occurred in any case, and no amputations were necessary. Local transcatheter intraarterial administration of urokinase can be considered a first-line treatment for brachial artery embolus and other causes of acute upper-extremity arterial occlusion.

KW - Arteries, extremities, 91.1274

KW - Arteries, stenosis or obstruction, 91.77

KW - Extremities, thrombosis, 91.77

KW - Fibrinolysis, 91.1274

KW - Streptokinase, 91.1274

KW - Thrombosis, arterial, 91.77

KW - Urokinase, 91.1274

UR - http://www.scopus.com/inward/record.url?scp=0025246283&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025246283&partnerID=8YFLogxK

M3 - Article

C2 - 2326466

AN - SCOPUS:0025246283

VL - 175

SP - 393

EP - 399

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 2

ER -