TY - JOUR
T1 - Fibrinolytic responses to moderate intensity exercise
T2 - Comparison of physically active and inactive men
AU - Szymanski, Linda M.
AU - Pate, Russell R.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1994
Y1 - 1994
N2 - The purposes of this study were to compare fibrinolytic responses to moderate intensity exercise in physically active and inactive men and during morning and evening exercise. Fourteen physically inactive men (mean age, 34.7±4.0 years) and 12 regularly active men (34.8±4.0 years) performed two exercise sessions, morning and evening, at 50% of maximal oxygen consumption. Tissue plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) activity were measured before and after exercise. Data were analyzed using a three-way ANOVA with repeated measures. TPA activity increased with exercise in both groups, although the active group demonstrated greater increases than the inactive group. Postexercise TPA activity was greater with evening than morning exercise. The inactive group exhibited greater PAI-1 activity than the active group. PAI-1 activity was higher during the morning than evening but did not change with exercise for either group. We conclude that moderate intensity exercise increases TPA activity in physically active and inactive men, with greater increases seen in active men, particularly during evening exercise. Moderate intensity exercise does not appear to affect PAI-1 activity. The lower PAI-1 activity in active men may be one mechanism whereby regular physical activity lowers the risk for coronary artery disease.
AB - The purposes of this study were to compare fibrinolytic responses to moderate intensity exercise in physically active and inactive men and during morning and evening exercise. Fourteen physically inactive men (mean age, 34.7±4.0 years) and 12 regularly active men (34.8±4.0 years) performed two exercise sessions, morning and evening, at 50% of maximal oxygen consumption. Tissue plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) activity were measured before and after exercise. Data were analyzed using a three-way ANOVA with repeated measures. TPA activity increased with exercise in both groups, although the active group demonstrated greater increases than the inactive group. Postexercise TPA activity was greater with evening than morning exercise. The inactive group exhibited greater PAI-1 activity than the active group. PAI-1 activity was higher during the morning than evening but did not change with exercise for either group. We conclude that moderate intensity exercise increases TPA activity in physically active and inactive men, with greater increases seen in active men, particularly during evening exercise. Moderate intensity exercise does not appear to affect PAI-1 activity. The lower PAI-1 activity in active men may be one mechanism whereby regular physical activity lowers the risk for coronary artery disease.
KW - Diurnal variations
KW - Fibrinolysis
KW - Physical fitness
KW - Plasminogen activator inhibitor
KW - Tissue plasminogen activator
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U2 - 10.1161/01.ATV.14.11.1746
DO - 10.1161/01.ATV.14.11.1746
M3 - Article
C2 - 7947599
AN - SCOPUS:0028152781
VL - 14
SP - 1746
EP - 1750
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 11
ER -