Fibrinolytic abnormalities in two different cutaneous manifestations of venous disease

D. J. Margolis, E. K.O. Kruithof, M. Barnard, K. Howe, G. S. Lazarus

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Chronic venous insufficiency may be associated with lipodermatosclerosis or atrophie blanche. Coagulation abnormalities may be related to these cutaneous disorders. Objective: Our purpose was to determine whether fibrinolytic abnormalities exist in patients with lipodermatosclerosis or atrophie blanche. Methods: A case control study of patients with venous disease and atrophie blanche or lipodermatosclerosis was performed. Plasma levels of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) in a resting and venous occluded state were measured. Results: Plasma levels of PAI-1 were different between the two groups of patients. The lipodermatosclerosis group had significantly higher levels of PAI-1 in both the resting and venous occluded states (p < 0.001). Patients with atrophic blanche had milder elevations of PAI-1 in the resting and venous occluded state (p = 0.06). Conclusion: Fibrinolytic abnormalities are present in patients with venous disease. These abnormalities are different between patients with lipodermatosclerosis and patients with atrophie blanche.

Original languageEnglish (US)
Pages (from-to)204-208
Number of pages5
JournalJournal of the American Academy of Dermatology
Volume34
Issue number2 I
DOIs
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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